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作者

Hou, Xi‐ran Yan, Zhen‐yu Liu, Shuang Gao, Na Chen, Jian Wang, Ya‐wen Wang, Liang Li, Zhao Wang, Xin‐ru Dong, Qiao‐feng Wang, Qiu‐yan Sun, Lin Wang, Yan‐ming Ma, Ji Zhao, Ya‐jing Xu, Zhi‐long Cao, Cong‐cong Peng, Jun Hou, Ming Liu, Xin‐guang

作者单位

¹Department of Hematology, Cheeloo College of Medicine, Qilu Hospital of Shandong University ²Department of Hematology, North China University of Science and Technology Affiliated Hospital ³Department of Hematology, Tai'an Central Hospital ⁴Department of Hematology, Binzhou Medical University Hospital ⁵Department of Hematology, Jining No. People's Hospital ⁶Department of Hematology, Shengli Oilfield Central Hospital ⁷Department of Hematology, Qilu Hospital of Shandong University ⁸Department of Hematology, Liaocheng People's Hospital ⁹Department of Hematology, Heze Municipal Hospital ¹⁰Department of Hematology, Qilu Hospital of Shandong University Dezhou Hospital ¹¹Department of Hematology, Central Hospital Affiliated to Shandong First Medical University ¹²Department of Hematology, Yantai Yuhuangding Hospital ¹³Department of Hematology, Shandong First Medical University Affiliated Tumor Hospital ¹⁴Department of Hematology, Lanling Hospital ¹⁵Department of Hematology, Qilu Hospital of Shandong University Pingyi Hospital

刊名

British Journal of Haematology

年份

2024

页码

1

ISSN

0007-1048

关键词

corticosteroids ITP metformin sustained response T2DM

摘要

Corticosteroids are the standard first‐line treatment for primary immune thrombocytopenia , with a high initial response but unsatisfactory sustained response . Additionally, corticosteroids usually lead to hyperglycaemia especially in patients with pre‐existing type 2 diabetes mellitus . Besides reducing the blood glucose levels, metformin was found to have immunomodulatory effects. We hereby conducted a multicentre propensity score matching analysis of corticosteroids plus metformin versus cor...更多

Corticosteroids are the standard first‐line treatment for primary immune thrombocytopenia , with a high initial response but unsatisfactory sustained response . Additionally, corticosteroids usually lead to hyperglycaemia especially in patients with pre‐existing type 2 diabetes mellitus . Besides reducing the blood glucose levels, metformin was found to have immunomodulatory effects. We hereby conducted a multicentre propensity score matching analysis of corticosteroids plus metformin versus corticosteroids for newly diagnosed ITP patients with pre‐existing T2DM. After matching at a ratio of 1:1, there were 57 patients in each group. Baseline characteristics, comorbidities and other medications including concurrent hypoglycaemic medications were balanced between the two groups. No statistical difference was observed in the initial response rate at day 14. It was notable that patients in the metformin group had a significantly higher SR rate and longer duration of response compared to the non‐metformin group. Metformin inclusion was associated with a higher incidence of stomach upset, which were generally tolerable. Our study provided evidence that the addition of metformin to corticosteroids might be a promising front‐line treatment for newly diagnosed ITP patients with pre‐existing T2DM.收起

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