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作者

王智超 张龙洋 仇梦真 高兴华 高相芹

作者单位

山东大学附属济南市中心医院泌尿外科，山东 济南 山东第一医科大学附属中心医院泌尿外科，山东 济南

刊名

Advances in Clinical Medicine

年份

2024

卷号

Vol.14 No.4

页码

156-173

ISSN

2161-8712

关键词

肾脏透明细胞癌(KIRC)、泛凋亡相关基因(PRG)、差异表达基因(DEG)、孟德尔随机化(MR)分析、诺模图 Kidney Renal Clear Cell Carcinoma (KIRC) PANoptosis-Related Genes (PRG) Differentially Expressed Genes (DEG) Mendelian Randomization (MR) Analysis Diagnostic Nomogram

摘要

Kidney renal clear cell carcinoma is a common genitourinary malignancy, however, it is quite difficult to detect and diagnose at an early stage. PANoptosis emphasizes the role and coordination between pyroptosis, apoptosis and necroptosis. The aim of this study is to identify the role of PANoptosis-related genes in KIRC and reveal their causal relationship by Mendelian randomization analysis. By intersecting 3446 differentially expressed genes and 347 PRGs obtained, we found that 66 differen...更多

Kidney renal clear cell carcinoma is a common genitourinary malignancy, however, it is quite difficult to detect and diagnose at an early stage. PANoptosis emphasizes the role and coordination between pyroptosis, apoptosis and necroptosis. The aim of this study is to identify the role of PANoptosis-related genes in KIRC and reveal their causal relationship by Mendelian randomization analysis. By intersecting 3446 differentially expressed genes and 347 PRGs obtained, we found that 66 differentially expressed-PANoptosis related genes existed expression quantitative trait loci . Two-sample univariate and multivariate MR analysis were performed respectively, and identified that causal relationships between PRF1 , TNFRSF10B , PDGFRB genes and KIRC disease, and the PDGFRB gene is a direct factor when the 3 marker genes were present simultaneously. Furthermore, model for KIRC with good diagnostic value were established based on bioinformatic analysis. Finally, the expression of marker genes was verified by data analysis and real-time fluorescence quantitative PCR .收起

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