Objective: This study aims to examine the incidence, clinical presentations, and contributing factors of hemodynamically significant patent ductus arteriosus among extremely preterm infants during their initial days of life. Methods: Utilizing a retrospective cohort design, we reviewed records of 9865 preterm infants from the SNN database spanning January 1, 2019, to August 1, 2023. Infants meeting specific inclusion criteria were selected to identify correlates of hsPDA onset. Demographic vari...更多
Objective: This study aims to examine the incidence, clinical presentations, and contributing factors of hemodynamically significant patent ductus arteriosus among extremely preterm infants during their initial days of life. Methods: Utilizing a retrospective cohort design, we reviewed records of 9865 preterm infants from the SNN database spanning January 1, 2019, to August 1, 2023. Infants meeting specific inclusion criteria were selected to identify correlates of hsPDA onset. Demographic variables and clinical data were collected. Cases were dichotomized into hsPDA and non-hsPDA categories for a nuanced comparison of incidence rates, clinical profiles, and demographic traits. Results: Our analyses revealed that reduced gestational age and birth weight are positively correlated with an increased incidence of hsPDA. Furthermore, our findings suggest that twin/multiple births, assisted reproductive technologies, maternal medical conditions , intubation at delivery, and extended postnatal respiratory support are potentially linked to the development of hsPDA. Conclusion: The disparities in the early life of extremely preterm infants may affect the postnatal occurrence of hsPDA. These findings could offer clinicians a foundation for early diagnosis and targeted intervention strategies.收起
