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作者

Weike Liu, Hua Zhang, Xin Wang, Huajing Song, Yanli Yao, Zhendong Liu, Juan Wang, Yuqi Guo

作者单位

com. ⁷ Department of Cardiology, The Second Hospital of Shandong University, No. 247, Beiyuan Street, Jinan, 250012, Shandong, China. moonlikewang@16 com. ⁶ Cardio-Cerebrovascular Diseases Control and Research Center, Clinical and Basic Medicine College, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, 250117, Shandong, China. zhendongliu876@12 Affiliations ¹ Department of Cardiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, 150001, Heilongjiang, China. ² Department of Cardiology, The First Affiliated Hospital of Shandong First Medical University, No. 16766, Jingshi Road, Jinan, 250014, Shandong, China. ³ Cardio-Cerebrovascular Diseases Control and Research Center, Clinical and Basic Medicine College, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, 250117, Shandong, China. ⁴ Department of Cardiology, The Second Hospital of Shandong University, No. 247, Beiyuan Street, Jinan, 250012, Shandong, China. ⁵ Department of Cardiology, The First Affiliated Hospital of Shandong First Medical University, No. 16766, Jingshi Road, Jinan, 250014, Shandong, China. zhendongliu876@12 com. ⁸ Department of Cardiology, The First Affiliated Hospital of Shandong First Medical University, No. 16766, Jingshi Road, Jinan, 250014, Shandong, China. guoyuqiyky@12 com. ⁹ Cardio-Cerebrovascular Diseases Control and Research Center, Clinical and Basic Medicine College, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, 250117, Shandong, China. guoyuqiyky@12 com.

刊名

Cardiovascular diabetology

年份

2025

卷号

Vol.24 No.1

页码

157

ISSN

1475-2840

关键词

Combined effect Dual-trajectory analysis Heart failure Insulin resistance Muscle mass loss.

摘要

Background: Skeletal muscle mass loss and insulin resistance are associated with cardiovascular diseases risk. However, it remains unclear whether the combination of skeletal muscle mass loss and elevated IR affects heart failure risk. Here, we investigate the association between a combination of appendicular skeletal muscle mass index with estimated glucose disposal rate and HF risk in older adults. Methods: A prospective analysis and a dual-trajectory analysis were carried out to investiga...更多

Background: Skeletal muscle mass loss and insulin resistance are associated with cardiovascular diseases risk. However, it remains unclear whether the combination of skeletal muscle mass loss and elevated IR affects heart failure risk. Here, we investigate the association between a combination of appendicular skeletal muscle mass index with estimated glucose disposal rate and HF risk in older adults. Methods: A prospective analysis and a dual-trajectory analysis were carried out to investigate the association of the combined effect of ASMI and eGDR with HF risk. A total of 11,596 adults aged ≥ 60 years were enrolled from the community for prospective analysis. Among them, 10,489 were eligible for the dual-trajectory analysis. The temporal evolution of ASMI and eGDR was determined using a dual-trajectory model. Results: In the prospective analysis, 1087 individuals developed HF. Restricted cubic splines analysis showed L-shaped associations between ASMI and eGDR and HF risk. HF risk decreased by 32.3% : 0.677, 95% confidence interval : 0.623-0.734, P = 0.003) for male patients per one standard deviation AMSI increment and 29.4% in group 3 with low-decrease ASMI and high-decrease eGDR. Conclusions: Skeletal muscle mass loss and elevated IR act synergistically to increase the HF risk in older adults. Comprehensive management of muscle mass and IR might be a useful and effective strategy for preventing and controlling HF.收起

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