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作者

Zhang, Hongzhi Yu, Yongmei Li, Hongda Wang, Xiuhuan Liu, Xinzhou Chen, Shengli Liu, Hong

作者单位

^bShandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences, Jinan, 250022, China ^aHospital for Skin Diseases, Shandong First Medical University, Jinan, 250022, China

刊名

China Journal of Leprosy and Skin Diseases

年份

2025

卷号

Vol.41 No.4

页码

267-271

ISSN

1009-1157

关键词

localized scleroderma reflectance confocal microscopy skin fibrosis

摘要

Objective: To evaluate the application value of reflectance confocal microscopy in the follow-up of localized scleroderma. Methods: Retrospectively analyze the RCM image characteristics of 14 patients with localized scleroderma confirmed by histopathology in our hospital during the follow - up period , and analyze the correlation with the efficacy of the patients. Results: After 12-15 months treatment, 13 out of 14 patients showed improvement, with decreased mLoSSI and LoSDI scores. One patient...更多

Objective: To evaluate the application value of reflectance confocal microscopy in the follow-up of localized scleroderma. Methods: Retrospectively analyze the RCM image characteristics of 14 patients with localized scleroderma confirmed by histopathology in our hospital during the follow - up period , and analyze the correlation with the efficacy of the patients. Results: After 12-15 months treatment, 13 out of 14 patients showed improvement, with decreased mLoSSI and LoSDI scores. One patient's condition deteriorated, with no change in the mLoSSI score and an increased LoSDI score. RCM changes in the 13 improved patients: In 6 patients, the collagen fibers recovered to a fine reticular structure, and in 7 patients, the dermal collagen density decreased; the dermal reflectance index of all 13 patients decreased; the clarity of the dermo-epidermal junction was significantly improved in 7 patients, and dermal microcirculation was visible in 4 patients. In the patient with deteriorated condition, there were no obvious improvements in the collagen fiber morphology, dermal reflectance index, and clarity of the dermo - epidermal junction. Conclusion: RCM is an effective tool for monitoring the collagen morphological changes and vascular alterations in localized scleroderma.收起

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