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作者

Wang, Qiuting Yang, Xinhao Yang, Zhengyu Hu, Xinyan Yuan, Jiehong Li, Maoyu Ma, Xiaotong Wang, Xiang Qiu, Chengxuan Sun, Qinjian

作者单位

^bKey Laboratory of Endocrine Glucose and Lipids Metabolism and Brain Aging, Ministry of Education, Department of Neurology, Shandong Provincial Hospital, Shandong First Medical University, Jinan, China ^aDepartment of Neurology, Shandong Provincial Hospital, Shandong University, Jinan, China ^cAging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm University, Stockholm, Sweden

刊名

Obesity Facts

年份

2025

ISSN

1662-4025

关键词

Abdominal volume index Arteriosclerosis Asymptomatic intracranial atherosclerosis Magnetic resonance imaging Population-based study

摘要

Introduction: The abdominal volume index , a novel anthropometric index that reflects abdominal obesity, has been related to atherosclerosis. We sought to investigate the association of AVI with the severity and burden of asymptomatic intracranial arterial stenosis in a rural Chinese population. Methods: The population-based cross-sectional study included 1,994 participants who were aged ≥40 years and living in Kongcun Town, Pingyin County, Shandong, and who had no history of clinical stroke or...更多

Introduction: The abdominal volume index , a novel anthropometric index that reflects abdominal obesity, has been related to atherosclerosis. We sought to investigate the association of AVI with the severity and burden of asymptomatic intracranial arterial stenosis in a rural Chinese population. Methods: The population-based cross-sectional study included 1,994 participants who were aged ≥40 years and living in Kongcun Town, Pingyin County, Shandong, and who had no history of clinical stroke or transient ischemic attack. We detected aICAS by combining transcranial Doppler ultrasound with magnetic resonance angiography. We used multiple logistic regression models to investigate the association between AVI and aICAS. Results: Of the 1,994 participants, 146 were diagnosed with aICAS, including 51 with mild aICAS and 95 with moderate-to-severe aICAS. Controlling for confounding factors, a greater AVI was significantly associated with an adjusted odds ratio of 1.08 for having aICAS, 1.11 for moderate-to-severe aICAS, and 1.12 for multiple moderate-to-severe aICAS. We detected a statistical interaction of AVI with hypertension on aICAS . Stratified analysis by hypertension showed a significantly independent association between AVI and aICAS in participants with hypertension but not in those without hypertension. Conclusion: A greater AVI is independently associated with aICAS, especially among individuals with hypertension. Moreover, AVI may help to identify both the severity and burden of aICAS.收起

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