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作者

He, Yujie Sun, Lin Song, Shaoxia Zhang, Shu Wu, Julong Dong, Yang Li, Zhong Wang, Xianjun Kou, Zengqiang Liu, Ti

作者单位

^cSchool of Public Health and Health Management, Shandong First Medical University, Jinan, 250117, China ^aShandong Provincial Center for Disease Control and Prevention, Shandong Institute of Preventive Medicine, Shandong Provincial Key Laboratory of Intelligent Monitoring, Early Warning and Prevention of Infectious Diseases, Jinan, 250014, China ^bJinan Second Maternal and Child Health Care Center, Jinan, 271100, China ^dSchool of Public Health, Shandong Second Medical University, Weifang, 261053, China

刊名

Chinese Journal of Epidemiology

年份

2025

卷号

Vol.46 No.3

页码

430-439

ISSN

0254-6450

关键词

Epidemiological characteristic Genetic characteristic Influenza Surveillance

摘要

Objective To analyze the epidemiological, etiological and genetic characteristics of influenza virus in Shandong Province during 2023-2024. Methods The surveillance data of influenza-like illness in sentinel hospitals in Shandong from 2023 to 2024 were collected and analyzed. The isolated influenza strains with hemagglutination titers ≥8 were selected for antigenicity analysis, drug susceptibility test, gene sequencing and evolutionary analysis. Results From 2023 to 2024, the positive rate of i...更多

Objective To analyze the epidemiological, etiological and genetic characteristics of influenza virus in Shandong Province during 2023-2024. Methods The surveillance data of influenza-like illness in sentinel hospitals in Shandong from 2023 to 2024 were collected and analyzed. The isolated influenza strains with hemagglutination titers ≥8 were selected for antigenicity analysis, drug susceptibility test, gene sequencing and evolutionary analysis. Results From 2023 to 2024, the positive rate of influenza virus in Shandong was 8.51% , the highest positive rate was in the age group of 5-14 years , and the highest positive rate was in the 49 week . Both antigenicity analysis and evolutionary analysis showed that the Apdm09 subtype and B strain had good matching effect and close evolutionary distance with the 2023-2024 surveillance year vaccine strain. The A subtype strain did not have a high matching effect with the 2023-2024 vaccine strain and had a long evolutionary distance, but had a close evolutionary distance with the 2024-2025 vaccine strain. Drug susceptibility test showed that oseltamivir sensitivity of influenza Apdm09 strain decreased greatly, and the amino acid site mutation of neuraminidase was H275Y. Conclusions In the 2023-2024 surveillance year, the peak of influenza virus epidemic in Shandong was mainly occurred in winter and spring, and the age group of 5-14 years was the focus of prevention and control. The dominant strain was subtype A, which had poor matching effect with the vaccine strain in the 2023-2024 surveillance year. One Apdm09 resistant strain was found in the drug resistance monitoring work. Follow-up prevention and control work should be strengthen the surveillance for the epidemiological characteristics, genetic variation and drug resistance of influenza viruses, timely understand the epidemic trend and mutation of influenza viruses, timely discover drug-resistant strains of influenza viruses, promote influenza vaccination, and improve of influenza prevention and control.收起

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