Affiliations 1 Academy of Medical Engineering and Translational Medicine, Medical College, Tianjin University, Tianjin, 300072, China. 2 State Key Laboratory of Advanced Medical Materials and Devices, Tianjin University, Tianjin, 300072, China. 3 Department of Orthopedics, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, 250021, China. 4 Medical College, Linyi University, Linyi, 276000, China.
With the development of bioelectronic devices, achieving adaptive therapy in dynamic environments remains challenging. Traditional electrostimulation struggles with external power dependence, insufficient responsiveness, and lack of environmental adaptability. This study presents a humidity-responsive moisture-electric generator that autonomously delivers dual-mode electrostimulation tailored to dynamic physiological environments, addressing a long-standing challenge in adaptive bioelectronic t...更多
With the development of bioelectronic devices, achieving adaptive therapy in dynamic environments remains challenging. Traditional electrostimulation struggles with external power dependence, insufficient responsiveness, and lack of environmental adaptability. This study presents a humidity-responsive moisture-electric generator that autonomously delivers dual-mode electrostimulation tailored to dynamic physiological environments, addressing a long-standing challenge in adaptive bioelectronic therapy. The MEG is engineered using 3D-printed nanocomposites integrating a hygroscopic PEDOT:PSS/graphene oxide core and a mechanically robust polycaprolactone structure, enabling humidity-gated voltage modulation. Under low-humidity conditions , the MEG produces therapeutic voltages that disrupt cytoskeletal integrity, improve chemotherapeutic drug penetration, and activate TNF-α/NF-κB signaling, resulting in immunogenic cell death and 88.34% tumor suppression. Transcriptomic analyses reveal distinct pathway engagement-calcium signaling dominates regenerative responses, while TNF cascades mediate antitumor immunity. This humidity-adaptive platform represents a closed-loop, self-powered therapeutic system that couples environmental sensing with intelligent bioelectronic output. Beyond its dual applications, the MEG introduces a transformative paradigm for autonomous, personalized medical intervention.收起
