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作者

Meng Jin Ge Gao Zeyu Liu Xiao Meng Haiyan Wei Wenwen Chen Hui Pan Mengping Zhang Qiang Jia Cuijuan Wang

作者单位

²Department of General Practice, Central Hospital Affiliated to Shandong First Medical University, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan 250000, China ¹Physical and Chemical Laboratory, Shandong Academy of Occupational Health and Occupational Medicine, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan 250000, China ³Department of Orthopaedics, China-Japan Union Hospital of Jilin University, Jilin University, Changchun 130033, China ⁴Toxicology Research Center, Shandong Academy of Occupational Health and Occupational Medicine, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan 250000, China

刊名

Sensors and Actuators B: Chemical

年份

2026

卷号

Vol.447 Part 2

页码

138883

ISSN

0925-4005

摘要

Public concern regarding the illicit addition of diphenhydramine to children’s cosmetics highlights the urgent need for robust point-of-use detection strategies. In addressing this concern, we present a surface-enhanced Raman scattering -based method for rapidly identifying and quantifying DPH in children’s creams. Our approach utilizes a multifunctional sensor comprising a cellulose nanofibrils film modified with metal-organic framework-801 and hedgehog-like gold nanoparticles . The synthes...更多

Public concern regarding the illicit addition of diphenhydramine to children’s cosmetics highlights the urgent need for robust point-of-use detection strategies. In addressing this concern, we present a surface-enhanced Raman scattering -based method for rapidly identifying and quantifying DPH in children’s creams. Our approach utilizes a multifunctional sensor comprising a cellulose nanofibrils film modified with metal-organic framework-801 and hedgehog-like gold nanoparticles . The synthesized GHPs/MOF-801/CNF sensor functions as both a SERS-active substrate and a sorbent, leveraging abundant nanogaps and sharp tips of the GHPs to amplify SERS signals. The porous CNF and MOF-801 ensure efficient and selective extraction, while the SERS-active GHPs significantly enhance detection sensitivity. The correlation between SERS intensity and logarithmic concentration yielded R-values between 0.926 and 0.978, with the detection limit as low as 0.4 ppb, making it suitable for detecting prohibited DPH additives. This method was successfully applied to two brands of cream samples, with results closely aligning with those from routine chromatography. This method’s key advantage is its exceptional efficiency, completing the detection process within 11 min, making it a user-friendly POU assay for detecting prohibited additives in children’s cosmetics.收起

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