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作者

Qiqi Qiao Shunfeng Hu Xin Wang

作者单位

Department of Hematology，Shandong Provincial Hospital Affiliated to Shandong First Medical University，Jinan，Shandong，P.R.China；Department of Hematology，Shandong Provincial Hospital，Shandong University，Jinan，Shandong，P.R.China

刊名

癌症通讯(英文版)

年份

2024

卷号

第44卷

期号

第7期

页码

761-786

关键词

glycolysis tumor development biomarkers targeted therapy

分类号

R343;R347.8;R977.15

摘要

Metabolic reprogramming has been demonstrated to have a significant impact on the biological behaviors of tumor cells,among which glycolysis is an important form.Recent research has revealed that the heightened glycolysis levels,the abnormal expression of glycolytic enzymes,and the accumulation of glycolytic products could regulate the growth,proliferation,invasion,and metastasis of tumor cells and provide a favorable microenvironment for tumor development and progression.Based on the distinctiv...更多

Metabolic reprogramming has been demonstrated to have a significant impact on the biological behaviors of tumor cells,among which glycolysis is an important form.Recent research has revealed that the heightened glycolysis levels,the abnormal expression of glycolytic enzymes,and the accumulation of glycolytic products could regulate the growth,proliferation,invasion,and metastasis of tumor cells and provide a favorable microenvironment for tumor development and progression.Based on the distinctive glycolytic characteristics of tumor cells,novel imaging tests have been developed to evaluate tumor proliferation and metastasis.In addition,glycolytic enzymes have been found to serve as promising biomarkers in tumor,which could provide assistance in the early diagnosis and prognostic assessment of tumor patients.Numerous glycolytic enzymes have been identified as potential therapeutic targets for tumor treatment,and various small molecule inhibitors targeting glycolytic enzymes have been developed to inhibit tumor development and some of them are already applied in the clinic.In this review,we systematically summarized recent advances of the regulatory roles of glycolysis in tumor progression and highlighted the potential clinical significance of glycolytic enzymes and products as novel biomarkers and therapeutic targets in tumor treatment.收起

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