3Department of Orthopaedic Surgery, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250012, PR China2College of Artificial Intelligence and Big Data for Medical Sciences, Shandong First Medical University, Jinan, 250117, PR China1Key Laboratory of High Efficiency and Clean Manufacturing, School of Mechanical Engineering, National Demonstration Center for Experimental Mechanical Engineering Education, Shandong University, Jinan, 250061, PR China
刊名
Biomaterials
年份
2026
卷号
Vol.327
页码
123749
ISSN
0142-9612
摘要
3D-printed porous Ti–6Al–4V implants are widely used in bone defect repair following osteosarcoma resection due to their favorable mechanical properties and biocompatibility. However, eliminating residual tumor cells, preventing bacterial infection, and ensuring effective osseointegration remain key challenges. In this paper, the implant containing a dual-release system was developed. First, a primary drug reservoir was constructed using nanotubes loaded with ZnO and rare earth elements . Second...更多
3D-printed porous Ti–6Al–4V implants are widely used in bone defect repair following osteosarcoma resection due to their favorable mechanical properties and biocompatibility. However, eliminating residual tumor cells, preventing bacterial infection, and ensuring effective osseointegration remain key challenges. In this paper, the implant containing a dual-release system was developed. First, a primary drug reservoir was constructed using nanotubes loaded with ZnO and rare earth elements . Second, a secondary phototherapy platform was created by coating the reservoir with a gelatin/sodium alginate hydrogel containing MgO, curcumin, and paclitaxel. Flow acid etching and anodic oxidation removed residuals and formed TiO nanotube arrays, while rare earth doping enhanced upconversion capability. Under 808 nm near-infrared irradiation , localized photothermal heating triggered hydrogel degradation, releasing the contents. Subsequently, the primary reservoir facilitated sustained Zn release alongside micro-nano cues. The modified surface demonstrated improved wettability and superior corrosion resistance. Meanwhile, the hydrogel exhibited near-complete degradation within 21 days, corresponding to the optimal therapeutic window following tumor resection. The biological experiments demonstrated that the dual-release system systematically inhibited tumor growth, eradicated bacterial infections, and promoted osteogenesis. Furthermore, this system modulated intracellular signaling pathways in both bone marrow mesenchymal stem cells and osteosarcoma cells . The system orchestrated metabolic reprogramming and modulated organelle dynamics. These coordinated effects simultaneously enhanced MSCs' osteogenic differentiation while inducing apoptosis in HOS. Furthermore, the system potentiated reactive oxygen species production, amplifying oxidative stress in bacterial populations. This strategy presents a therapeutic approach for post-resection osteosarcoma management.收起
