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作者

Zhegang Zhou, Xuhui Chen, Wei Kou, Fanbin Meng, Longbiao Yu, Jingjing Wen, Johnson Boey, Vitrag Shah, Paloma Malagón

作者单位

Affiliations ¹ From the Department of Hand and Microsurgery, Peking University Shenzhen Hospital, Shenzhen, China. ² Department of Neurology, Peking University Shenzhen Hospital, Shenzhen, China. ³ Department of Hand and Foot and Reconstructive Microsurgery, Shandong Affiliated Provincial Hospital of Shandong First Medical University, Shandong, China. ⁴ Department of Podiatry, Singhealth Polyclinics, Singapore, Singapore. ⁵ Department of Plastic Surgery, Shah Speciality Hospital, Surat, Gujarat, India. ⁶ Department of Plastic Surgery, Hospital Germans Trias i Pujol, Universitat Autònoma de Barcelona, Barcelona, Spain.

刊名

Plastic and reconstructive surgery. Global open

年份

2025

卷号

Vol.13 No.10

页码

e7082

ISSN

2169-7574

摘要

Alzheimer disease is a neurodegenerative disorder that frequently results in progressive cognitive decline. Despite the extensive research conducted on AD, there is presently no solution available due to its increasing prevalence. Recent research has suggested cervical lymphaticovenular anastomosis as a therapeutic strategy to improve lymphatic outflow and potentially reduce AD symptoms. We established an amended LVA protocol to mitigate the risk of venous reflux, a prevalent issue associated ...更多

Alzheimer disease is a neurodegenerative disorder that frequently results in progressive cognitive decline. Despite the extensive research conducted on AD, there is presently no solution available due to its increasing prevalence. Recent research has suggested cervical lymphaticovenular anastomosis as a therapeutic strategy to improve lymphatic outflow and potentially reduce AD symptoms. We established an amended LVA protocol to mitigate the risk of venous reflux, a prevalent issue associated with the original LVA methodology. A 64-year-old man of Chinese descent exhibited the typical signs and symptoms of AD. The absence of substantial progress with standard medical treatment led to the consideration of LVA. We used a lower limb vein graft for the LVA, anastomosing it to the cervical lymphatic vessels and external jugular vein. The cognitive function of the patient got better after LVA, as shown by higher Mini Mental State Examination and Montreal Cognitive Assessment scores. Fewer β-amyloid and tau protein deposits were observed on positron emission tomography/computed tomography scans. No adverse occurrences or issues were observed. The success in this case demonstrated the potential role of LVA in the management of AD. However, further thorough research is required to evaluate the efficacy of our technique.收起

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