获取途径

作者

Feng Ye, Ni Guo, Yaping Wang, Baochun Wang, Chunyan Niu, Zujin Ji, Ming Guo, Yilin Hou, Yi Jian, Jianhua Cui, Dazhi Chen, Shuhui Li, Dongxia Wang, Hongping Guo, Junlei Jiu, Chunlei Qiu, Hui Cao, Ying He, Ming Chen, Hua Li, Xuezhi Xin, Rongjuan Zheng, Wei Chen, Dongya Chen, Lingyun Niu, Zhenqin Cui, Zhanquan Zou, Bin Jia, Leyao Zhang, Yinming Bai, Wanyu Li, Xiaojun Yang, Min Hua, Shaoming Long, Guoliang Cheng, Zhiyan Huang, Enhua Yang, Jinjin Shi, Guoxin Zhang

作者单位

Affiliations ¹ Department of Gastroenterology, The First Affiliated Hospital with Nanjing Medical University, Nanjing, Jiangsu Province, China. ² Department of Gastroenterology, Dongying People's Hospital, Dongying, Shandong Province, China. ³ Department of Gastroenterology, Dengzhou Central Hospital, Nanyang, Henan Province, China. ⁴ Department of General Surgery, Hainan General Hospital, Haikou, Hainan Province, China. ⁵ Department of Gastroenterology, Nanjing Lishui People's Hospital, Nanjing, Jiangsu Province, China. ⁶ Department of Colorectal and Anal Surgery, Sinopharm Dongfeng General Hospital, Shiyan, Hubei Province, China. ⁷ Department of Gastroenterology, The First Affiliated Hospital of Zhejiang University School of Medicine, Huzhou, Zhejiang Province, China. ⁸ Department of Gastroenterology, Zhenjiang Hospital of Chinese Traditional and Western Medicine, Zhenjiang, Jiangsu Province, China. ⁹ Department of Gastroenterology and Hepatology, Chengdu Second People's Hospital, Chengdu, Sichuan Province, China. ¹⁰ Department of Gastroenterology, Dongtai People's Hospital, Yancheng, Jiangsu Province, China. ¹¹ Department of Gastrointestinal Vascular Surgery, Huaxian People's Hospital of Henan, Anyang, Henan Province, China. ¹² Department of Gastroenterology, Tengzhou Central People's Hospital, Zaozhuang, Shandong Province, China. ¹³ Digestive Center Internal Medicine Group, Shenyang Tenth People's Hospital, Shenyang, Liaoning Province, China. ¹⁴ Department of Anorectal, Qujing Hospital of Traditional Chinese Medicine, Qujing, Yunnan Province, China. ¹⁵ Department of Anorectal, Zhumadian TCM Hospital, Zhumadian, Henan Province, China. ¹⁶ Department of Gastroenterology, Affiliated Hospital of Jinggangshan University, Jian, Jiangxi Province, China. ¹⁷ Department of Gastrointestinal Surgery, Huainan Oriental Hospital Group General Hospital, Huainan, Anhui Province, China. ¹⁸ Department of Gastroenterology, Harbin First Hospital, Harbin, Heilongjiang Province, China. ¹⁹ Department of Gastroenterology, Tianjin Hospital of ITCWM, Nankai Hospital, Tianjin, China. ²⁰ Department of Endoscopy, Tianjin Cancer Hospital Airport Hospital, Tianjin, China. ²¹ Department of Anorectal, The First Affiliated Hospital of Shandong First Medical University, Jinan, Shandong Province, China. ²² Department of Gastroenterology, Tangshan Central Hospital, Tangshan, Hebei Province, China. ²³ Department of Gastroenterology, Xiangyang No People's Hospital, Xiangyang, Hubei Province, China. ²⁴ Department of Gastroenterology, Zhejiang Hospital of Integrated Traditional Chinese and Western Medicine, Hangzhou, Zhejiang Province, China. ²⁵ Department of Gastroenterology, Shanxi Bethune Hospital, Taiyuan, Shanxi Province, China. ²⁶ Department of Gastroenterology, Shengli Oilfield Central Hospital, Dongying, Shandong Province, China. ²⁷ Department of Anorectal, Yuebei People's Hospital, Shaoguan, Guangdong Province, China. ²⁸ Department of Gastroenterology, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong Province, China. ²⁹ Department of Gastroenterology, Wuxi Ninth People's Hospital Affiliated to Soochow University, Wuxi, Jiangsu Province, China. ³⁰ Department of Gastroenterology, The People's Hospital of Lvliang, Lvliang, Shanxi Province, China. ³¹ Department of Gastroenterology, Qinghai Red Cross Hospital, Xining, Qinghai Province, China. ³² Department of Gastroenterology, Wuxi Xishan People's Hospital, Wuxi, Jiangsu Province, China. ³³ Department of Gastroenterology, Shengze Hospital of Nanjing Medical University, Suzhou, Jiangsu Province, China. ³⁴ Department of Gastroenterology, The People's Hospital of Xiang Yun, Dali, Yunnan Province, China. ³⁵ State Key Laboratory of Integration and Innovation of Classic Formula and Modern Chinese Medicine, Linyi, Shandong Province, China. ³⁶ Department of Gastroenterology, The First Affiliated Hospital with Nanjing Medical University, No. 300 Guangzhou Road, Nanjing, Jiangsu Province 210029, China.

刊名

Therapeutic advances in gastroenterology

年份

2025

卷号

Vol.18

ISSN

1756-283X

关键词

Shouhui Tongbian Capsules bowel preparation colonoscopy polyethylene glycol.

摘要

Background: High-volume polyethylene glycol solutions are commonly used for bowel preparation but are often poorly tolerated, reducing patient compliance. Shouhui Tongbian Capsules , a traditional Chinese medicine known to promote gastrointestinal motility, may offer an alternative approach. However, its role in bowel preparation remains unclear. Objectives: To evaluate the efficacy, safety, and tolerability of a novel bowel preparation regimen combining SHTBC with low-volume PEG compared to c...更多

Background: High-volume polyethylene glycol solutions are commonly used for bowel preparation but are often poorly tolerated, reducing patient compliance. Shouhui Tongbian Capsules , a traditional Chinese medicine known to promote gastrointestinal motility, may offer an alternative approach. However, its role in bowel preparation remains unclear. Objectives: To evaluate the efficacy, safety, and tolerability of a novel bowel preparation regimen combining SHTBC with low-volume PEG compared to conventional high-volume PEG . Design: Multicenter, randomized, single-blind, parallel-controlled trial. Methods: A total of 404 participants scheduled for colonoscopy across 34 medical centers in China were randomized into two groups: the experimental group and the control group . Bowel preparation quality was assessed using the Boston Bowel Preparation Scale , with successful cleansing defined as a total BBPS score ⩾6. The secondary outcomes included time to adequate bowel movement, number of bowel movements, patient tolerance, acceptance, and incidence of adverse drug reactions . Results: The success rate of bowel preparation was comparable between groups . The experimental group had a slightly longer time to first adequate bowel movement on the day of colonoscopy but experienced fewer bowel movements the day before . The experimental group reported significantly fewer ADRs and better tolerance, including reduced bloating, nausea, and sleep disturbance . Patient acceptance was higher in the experimental group , although the difference was not statistically significant . Conclusion: SHTBC combined with 2L PEG is a safe, effective, and better-tolerated alternative to 3L PEG for bowel preparation before colonoscopy, offering a promising strategy to improve patient compliance. Trial registration: Chinese Clinical Trial Registry: ChiCTR2300069962.收起

文献类型

期刊