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作者

Guangrui Li Shenglong Zhang Qingyao Zhong Meiling Weng

作者单位

^{3 2a School of Ophthalmology, Shandong First Medical University, Jinan, China Department of Anesthesiology, Shanghai Geriatric Medical Center, Shanghai, China 1a School of Ophthalmology, Shandong First Medical University, Jinan, China 4 Department of Anesthesiology, Zhongshan Hospital, Fudan University, Shanghai, China}

刊名

Materials Technology

年份

2025

卷号

Vol.40 No.1

页码

2569362

ISSN

1066-7857

关键词

Hybrid hydrogel ocular surface interaction ROS clearance dry eye disease management injectable materials inflammation clearance surgical management anesthesia

摘要

Dry eye disease is a common chronic ocular disorder leading to corneal epithelial cell injury and death during general anesthesia. Recent studies have focused on reactive oxygen species clearance, but existing strategies lack the ability to prolong drug retention time and addressing both corneal epithelial cell protection and ROS clearance synergistically. Hydrogels have emerged as a promising approach. However, the application of tannic acid and Ce in hydrogels for DED treatment remains unde...更多

Dry eye disease is a common chronic ocular disorder leading to corneal epithelial cell injury and death during general anesthesia. Recent studies have focused on reactive oxygen species clearance, but existing strategies lack the ability to prolong drug retention time and addressing both corneal epithelial cell protection and ROS clearance synergistically. Hydrogels have emerged as a promising approach. However, the application of tannic acid and Ce in hydrogels for DED treatment remains underexplored. This study proposes a smart hydrogel based on gelatin, TA and Ce, forming a cross-linked network with dynamic covalent bonds. The hydrogel exhibited >90% ROS clearance efficiency, ~95% human corneal epithelial cell viability after 24 h of co-culture, and ~90% intracellular ROS clearance under oxidative stress. These results indicate that the Gel-TA@Ce hydrogel effectively prevents oxidative damage while maintaining excellent cytocompatibility, addressing the limitations of current dry eye disease treatments.收起

文献类型

期刊