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作者

Meng Yin Haojun Shi Cui Lv Liang Shi Liangyu Xie Gongchang Yu Kai Xu

作者单位

⁵Medical Science and Technology Innovation Center, Medical Science and Technology Innovation Center, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan 271016, China ³These authors contributed equally to this work. ²Shandong Academy of Occupational Health and Occupational Medicine, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan 271016, China ⁶Shandong Institute of Brain Science and Brain-inspired Research, Medical Science and Technology Innovation Center, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan 271016, China ⁴Faculty of Chinese Medicine and State Key Laboratory of Quality Research in Chinese Medicines, Macau University of Science and Technology, Macau 999078, China ¹Neck-Shoulder and Lumbocrural Pain Hospital of Shandong First Medical University, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan 271016, China

刊名

Medicine Plus

年份

2025

页码

100104

ISSN

2950-3477

关键词

Brain Bone Brain-bone axis Neuromolecules Extracellular vesicles

摘要

The brain serves as the core component of the central nervous system and plays a pivotal role in regulating the functions of various essential organs throughout the body. The skeletal system serves as the fundamental supportive and protective framework of the human body, and is extensively innervated by nerves. Currently, a large body of epidemiological and experimental evidence confirms the close interplay between bones and the brain, but the underlying mechanisms remain unclear. This review is...更多

The brain serves as the core component of the central nervous system and plays a pivotal role in regulating the functions of various essential organs throughout the body. The skeletal system serves as the fundamental supportive and protective framework of the human body, and is extensively innervated by nerves. Currently, a large body of epidemiological and experimental evidence confirms the close interplay between bones and the brain, but the underlying mechanisms remain unclear. This review is anchored on the concept of the brain-bone axis, aiming to gain a deeper understanding of the physiological and pathological interactions between these two organs. A comprehensive analysis of the potential foundations and mechanisms underlying the intricate association between the brain and the skeleton is offered. In summary, the brain can influence skeletal homeostasis through modulation of the neuromolecules, extracellular vesicles, and brain-marrow neural circuit, conversely the skeleton can influence the brain in its development, function, and pathology by physical exercise, massage therapy, and skeletal trauma. Simultaneously, the strategies for the treatment of skeletal and neurological disorders were organized, in which Traditional Chinese Medicine appears to offer new perspectives for the prevention and disease management, ultimately aiming to furnish patients with more effective therapeutic methods.收起

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