Peritumoral and intratumoral magnetic resonance imaging-based radiomics of brain metastases for predicting the response to EGFR-tyrosine kinase inhibitors in metastatic non-small cell lung cancer
Department of Radiology，Shandong Provincial Hospital Affiliated to Shandong First Medical University，Jinan，China；Department of Radiology，Beijing Chest Hospital，Capital Medical University，Beijing，China；Department of Radiology，Beijing Chest Hospital，Capital Medical University，Beijing，China；Department of Radiology，Beijing Chest Hospital，Capital Medical University，Beijing，China；Department of Radiology，Beijing Chest Hospital，Capital Medical University，Beijing，China；Department of Radiology，Shandong Cancer Hospital and Institute，Shandong First Medical University，Shandong Academy of Medical Sciences，Jinan，China；Department of Radiology，Beijing Chest Hospital，Capital Medical University，Beijing，China
BackgroundThe early prediction of treatment response for EGFR-tyrosine kinase inhibitors is critical to guiding therapy in patients with metastatic non-small cell lung cancer . This study aimed to develop a magnetic resonance imaging -based radiomics model based on intratumoral and peritumoral regions to assess the response of patients with metastatic NSCLC to EGFR-TKIs.MethodsWe retrospectively recruited 418 and 160 patients with brain metastases from EGFR-mutant NSCLC who received EGFR-TKI t...更多
BackgroundThe early prediction of treatment response for EGFR-tyrosine kinase inhibitors is critical to guiding therapy in patients with metastatic non-small cell lung cancer . This study aimed to develop a magnetic resonance imaging -based radiomics model based on intratumoral and peritumoral regions to assess the response of patients with metastatic NSCLC to EGFR-TKIs.MethodsWe retrospectively recruited 418 and 160 patients with brain metastases from EGFR-mutant NSCLC who received EGFR-TKI therapy from hospital 1 and hospital 2, respectively. The intratumoral region of interest was manually segmented for contrast-enhanced T1-weighted imaging. Five peritumoral ROIs at 2-, 4-, 6-, 8-, and 10-mm expansions along ROI_I were defined, and combined ROIs were automatically generated. The least absolute shrinkage and selection operator was used to select the most predictive features, which was followed by the construction of radiomics models . The area under the curve and Shapley method were used to validate the performance of the models and explain the best models.ResultsThe combined intratumoral and peritumoral 6-mm regions achieved the best performance, with AUCs of 0.913 and 0.826 in the training and test cohort. The ROI_I model also demonstrated a degree of classification power in both the training and test cohort, with AUCs of 0.868 and 0.762, respectively.ConclusionsAs compared to models consisting of intratumoral or peritumoral radiomics features alone, the model combining intratumoral and peritumoral radiomics features achieved better performance in predicting therapeutic response to EGFR-TKIs. The optimal combined region model with 6-mm peritumoral expansion along the tumor may benefit the clinical treatment of NSCLC.收起
发文期刊《Peritumoral and intratumoral magnetic resonance imaging-based radiomics of brain metastases for predicting the response to EGFR-tyrosine kinase inhibitors in metastatic non-small cell lung cancer》历年引证文献趋势图
