获取途径

作者

Fan, Hui Shao, Chunhong Wang, Jia Yang, Yang Hu, Fupin Zhu, Demei Chen, Yunsheng Meng, Qing Zhang, Hong Wang, Chun Dong, Fang Song, Wenqi Wen, Kaizhen Zhang, Yirong Wang, Chuanqing Fu, Pan Zhuo, Chao Su, Danhong Ke, Jiangwei Zhou, Shuping Zhang, Hua Hu, Fangfang Kang, Mei He, Chao Yu, Hua Huang, Xiangning Xu, Yingchun Zhang, Xiaojiang Liu, Wenen Li, Yanming Zhu, Lei Meng, Jinhua Wang, Shifu Shan, Bin Du, Yan Jia, Wei Li, Gang Feng, Jiao Gong, Ping Song, Miao Wei, Lianhua Wang, Xin Wang, Ruizhong Fang, Hua Guo, Sufang Wang, Yanyan Guo, Dawen Zhao, Jinying Zhang, Lixia Ma, Juan Shen, Han Zhou, Wanqing Guo, Ruyi Zhu, Yan Wu, Jinsong Lu, Yuemei Ni, Yuxing Sun, Jingrong Ma, Xiaobo Zheng, Yanqing Yu, Yunsong Lin, Jie Sun, Ziyong Chen, Zhongju Hu, Zhidong Li, Jin Zhang, Fengbo Ji, Ping Hu, Yunjian Ai, Xiaoman Duan, Jinju Kang, Jianbang Hu, Xuefei Xu, Xuesong Yan, Chao Li, Yi Wang, Shanmei Gu, Hongqin Xu, Yuanhong Huang, Ying Chu, Yunzhuo Tian, Sufei Li, Jihong Yu, Bixia Kou, Cunshan Shen, Jilu Huang, Wenhui Yang, Xiuli Zhu, Likang Jiang, Lin He, Wen Yue, Chunlei

作者单位

^aDepartment of Clinical Medicine Laboratory, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250021, China

刊名

Chinese Journal of Infection and Chemotherapy

年份

2025

卷号

Vol.25 No.1

页码

30-38

ISSN

1009-7708

关键词

antimicrobial resistance Haemophilus influenzae Moraxella catarrhalis β-lactamase

摘要

Objective To investigate the distribution and antimicrobial resistance profiles of clinically isolated Haemophilus influenzae and Moraxella catarrhalis in hospitals across China from 2015 to 2021, and provide evidence for rational use of antimicrobial agents. Methods Data of H. influenzae and M. catarrhalis strains isolated from 2015 to 2021 in CHINET program were collected for analysis, and antimicrobial susceptibility testing was performed by disc diffusion method or automated systems accordin...更多

Objective To investigate the distribution and antimicrobial resistance profiles of clinically isolated Haemophilus influenzae and Moraxella catarrhalis in hospitals across China from 2015 to 2021, and provide evidence for rational use of antimicrobial agents. Methods Data of H. influenzae and M. catarrhalis strains isolated from 2015 to 2021 in CHINET program were collected for analysis, and antimicrobial susceptibility testing was performed by disc diffusion method or automated systems according to the uniform protocol of CHINET. The results were interpreted according to the CLSI breakpoints in 2022. Betalactamases was detected by using nitrocefin disk. Results From 2015 to 2021, a total of 43 642 strains of Haemophilus species were isolated, accounting for 2.91% of the total clinical isolates and 4.07% of Gram-negative bacteria in CHINET program. Among the 40 437 strains of H. influenzae, 66.89% were isolated from children and 33.11% were isolated from adults. More than 90% of the H. influenzae strains were isolated from respiratory tract specimens. The prevalence of β-lactamase was 53.79% in H. influenzae strains. The H. influenzae strains isolated from children showed higher resistance rate than the strains isolated from adults. Overall, 779 strains of H. influenzae did not produce β-lactamase but were resistant to ampicillin . Beta-lactamase-producing strains showed significantly higher resistance rates to these antimicrobial agents than the β-lactamase-nonproducing strains. Of the 16 191 M. catarrhalis strains, 80.06% were isolated from children and 19.94% isolated from adults. M. catarrhalis strains were mostly susceptible to both amoxicillin-clavulanic acid and cefuroxime, evidenced by resistance rate lower than 2.0%. Conclusions The emergence of antibiotic-resistant H. influenzae due to β-lactamase production poses a challenge for clinical anti-infective treatment. Therefore, it is very important to implement antibiotic resistance surveillance for H. influenzae and guide rational antibiotic use. All local clinical microbiology laboratories should actively improve antibiotic susceptibility testing and strengthen antibiotic resistance surveillance for H. influenzae.收起

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