Progress in the role of reactive oxygen species induced by environmental factors on apolipoproteins in atherosclerosis

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作者单位: ^bSchool of Laboratory Animal, Shandong Laboratory Animal Center, Shandong First Medical University, Shandong Academy of Medical Sciences, Shandong, Ji'nan, 250117, China ^aSchool of Pharmacy, Institute of Materia Medica, Shandong First Medical University, Shandong Academy of Medical Sciences, Shandong, Ji'nan, 250117, China

关键词: apolipoprotein atherosclerosis cardiovascular disease environmental factors oxidative stress

摘要: Environmental factors such as air pollutants, plastic micro-particles, ionizing radiation, and traffic noise promote the onset and progression of atherosclerotic cardiovascular diseasethrough mechanisms including inducing inflammatory responses, promoting oxidative stress, and accelerating lipid deposition. Notably, the modification of apolipoprotein by reactive oxygen species accelerates this process. On one hand, ROS can oxidize key amino acid residues in Apo, altering its structure and ther...更多; Environmental factors such as air pollutants, plastic micro-particles, ionizing radiation, and traffic noise promote the onset and progression of atherosclerotic cardiovascular diseasethrough mechanisms including inducing inflammatory responses, promoting oxidative stress, and accelerating lipid deposition. Notably, the modification of apolipoprotein by reactive oxygen species accelerates this process. On one hand, ROS can oxidize key amino acid residues in Apo, altering its structure and thereby impairing its normal physiological function. On the other hand, ROS can induce lipid peroxidation of Apo, rendering the oxidized Apo more susceptible to recognition and uptake by macrophages. This accelerates foam cell formation and drives the progression of atherosclerotic plaques. This review summarizes recent research advances on the role of ROS-induced modification of Apo by environmental factors in atherosclerotic CVD.收起

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