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作者

Wenting Pei, Yanlong Duan, Ling Jin, Xiaomei Yang, Yunpeng Dai, Mincui Zheng, Leping Zhang, Ying Liu, Xiaojun Yuan, Kailan Chen, Lirong Sun, Jian Jiang, Xiaowen Zhai, Ansheng Liu, Rong Liu, Jian Wang, Wei Liu, Baoxi Zhang, Yufeng Liu, Xige Wang, Lian Jiang, Lihua Yang, Chunju Zhou, Zifen Gao, Yonghong Zhang, Fu Li

作者单位

Affiliations ¹ Children's Hospital Affiliated to Shandong University (Jinan Children's Hospital), Jinan, 250022, China. ² Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, 100045, China. ³ Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250021, China. ⁴ Hunan Children's Hospital, Changsha, 410007, China. ⁵ Peking University People's Hospital, Beijing, 100044, China. ⁶ Beijing Gobroad Boren Hospital, Beijing, 100070, China. ⁷ Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200092, China. ⁸ Wuhan Children's Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430016, China. ⁹ The Affiliated Hospital of Qingdao University, Qingdao, 266003, China. ¹⁰ Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, 201102, China. ¹¹ Xi'an Children's Hospital, Xi'an, 710002, China. ¹² Children's Hospital, Capital Pediatric Research Institute, Beijing, 100020, China. ¹³ Anhui Children's Hospital, Hefei, 230022, China. ¹⁴ Children's Hospital Affiliated to Zhengzhou University, Zhengzhou, 450018, China. ¹⁵ Second Hospital of Hebei Medical University, Shijiazhuang, 050004, China. ¹⁶ First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China. ¹⁷ Third Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China. ¹⁸ Forth Hospital of Hebei Medical University, Shijiazhuang, 050004, China. ¹⁹ Zhu jiang Hospital of Southern Medical University, Guangzhou, 510280, China. ²⁰ Beijing University, Thrid hospital, Beijing, 100191, China. ²¹ Beijing Gobroad Boren Hospital, Beijing, 100070, China. zhangyongh@borenhospital.com. ²² Children's Hospital Affiliated to Shandong University (Jinan Children's Hospital), Jinan, 250022, China. lifusd@12 com.

刊名

Annals of hematology

年份

2025

ISSN

1432-0584

关键词

Burkitt leukemia Children Clinical features Prognosis.

摘要

Burkitt lymphoma is a B-cell malignancy with a rapid doubling time, originating in follicular germinal centers. We aimed to explore the characteristics and prognosis of childhood Burkitt leukemia. A total of 124 children with Burkitt leukemia enrolled during the 6-year period of China Net Childhood Lymphoma- mature B-cell lymphoma 2017 regimen were assessed. The median age at onset was 7 years , with a male-to-female ratio of 4.17:1. Of the total, 50.8% children were aged 5-10 years. Children ...更多

Burkitt lymphoma is a B-cell malignancy with a rapid doubling time, originating in follicular germinal centers. We aimed to explore the characteristics and prognosis of childhood Burkitt leukemia. A total of 124 children with Burkitt leukemia enrolled during the 6-year period of China Net Childhood Lymphoma- mature B-cell lymphoma 2017 regimen were assessed. The median age at onset was 7 years , with a male-to-female ratio of 4.17:1. Of the total, 50.8% children were aged 5-10 years. Children with Burkitt leukemia were more likely to have tumor lysis syndrome, renal insufficiency, lactate dehydrogenase > 4 times, multiple organ involvement, and central nervous system infiltration at diagnosis, whereas those with large tumor mass were rare. Eleven children had pure Burkitt leukemia , with no significant differences in relapse, progression, white blood cell counts at initial diagnosis, LDH levels, CNS infiltration, and rates of tumor lysis syndrome before treatment compared to those of children with tumor masses. . The median follow-up time for the entire group was 32.85 months , with 3-year overall survival and event-free survival rates of 87.1% and 81.5%, respectively. Thirteen children progressed or relapsed during treatment, of which nine received chimeric antigen receptor T-cell therapy, with only three fatalities. The analysis identified residual disease at midterm evaluation and LDH elevation ≥ 2000 U/L as independent prognostic factors affecting survival. The CNCL-B-NHL-2017 protocol demonstrated significant efficacy in treating children with Burkitt leukemia.收起

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