aClinical Medical College, Shandong First Medical University, Shandong Academy of Medical Sciences, Shandong, Jinan, 250117, ChinabDepartment of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University, Shandong Academy of Medical Sciences, Shandong, Jinan, 250117, China
刊名
Chinese Journal of Cancer Prevention and Treatment
Objective To explore the application and research progress of minimal residual disease detection in radiotherapy for tumors, providing a reference for precision radiotherapy. Methods Pubmed and Chinese National knowledge Infrastructure database literature search system were used to search the relevant literature from June 23. 2013. to November 6. 2024 with the keywords of 'minimal residual disease; malignant tumor; radiotherapy;comprehensive treatment'. Inclusion criteria included application ...更多
Objective To explore the application and research progress of minimal residual disease detection in radiotherapy for tumors, providing a reference for precision radiotherapy. Methods Pubmed and Chinese National knowledge Infrastructure database literature search system were used to search the relevant literature from June 23. 2013. to November 6. 2024 with the keywords of 'minimal residual disease; malignant tumor; radiotherapy;comprehensive treatment'. Inclusion criteria included application and progress of minimal residual lesion detection in radiotherapy for cancer. Exclusion criteria: literature with outdated date; low-quality literature. A total of 48 articles were included. Results MRD detection can accurately reflect tumor residual status and provide a basis for individualized radiotherapy adjustments. Liquid biopsy, due to its non-invasive nature and high sensitivity, has become a research hot spot, while molecular imaging combined with novel radiotherapy modalities can enhance tumor control rates. The integration of multiple detection technologies can further improve the accuracy of MRD detection. Conclusion MRD detection holds great potential in tumor radiotherapy, contributing to optimized treatment strategies, improved therapeutic efficacy, and reduced recurrence risk. However, challenges such as the lack of standardized detection criteria and high technical costs remain. Future research should focus on optimizing detection methods and promoting the clinical translation of MRD dynamic monitoring in precision radiotherapy.收起
