Walnut-derived peptides ameliorate aluminum-induced cognitive impairment via miR-124-3p/STAT3-TGF- β1/Smad3 signaling pathway in rats

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作者: Zhang, Xiao-Yu Wang, Xiu-Feng Wang, Quan-Yue Wang, Bing-Yi Lin, Li Zhang, Jing Li, Huan

作者单位: ^aSchool of Public Health and Health Management, Shandong First Medical University, Shandong Academy of Medical Sciences, Shandong, Jinan, 250117, China

关键词: Aluminum Cognitive dysfunction MiR-124-3p STAT3-TGF-β1/Smad3 Walnut-derived peptides

摘要: Objective To investigate the effects of walnut-derived peptides on miR-124-3p, STAT3, TGF-β1, and Smad3 proteins in aluminum-induced cognitive impairment. Methods Forty male SD rats were divided into control , aluminum model 3), 45-day WDP treatment 3 + 800 mg/kg WDP from day 45), and 90-day WDP prevention 3 + 800 mg/kg WDP from day 1) groups . Cognitive function was assessed by Morris water maze. Hippocampal protein expressions and miR-124-3p levels were measured. Results Aluminum exposure pr...更多; Objective To investigate the effects of walnut-derived peptides on miR-124-3p, STAT3, TGF-β1, and Smad3 proteins in aluminum-induced cognitive impairment. Methods Forty male SD rats were divided into control , aluminum model 3), 45-day WDP treatment 3 + 800 mg/kg WDP from day 45), and 90-day WDP prevention 3 + 800 mg/kg WDP from day 1) groups . Cognitive function was assessed by Morris water maze. Hippocampal protein expressions and miR-124-3p levels were measured. Results Aluminum exposure prolonged escape latency from day 2 , which was attenuated by WDP . Aluminum increased hippocampal p-STAT3, TGF-β1, and p -Smad3 expressions while decreasing miR-124-3p . WDP interventions reversed these alterations . Conclusion WDP exerts protective effects against aluminum -induced cognitive dysfunction potentially through modulating miR-124-3p/STAT3-TGF-β1/Smad3 signaling pathway.收起

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