Adenovirus mediated Profurin expression improved the plaque stability of ApoEmice

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作者: Zhang, Xinyi Wang, Chen Yang, Wanyue Yang, Ze Ren, Guodong Zhang, Jiguo Yu, Yang Zhang, Ke

作者单位: ^dThe Second Affiliated Hospital of Shandong First Medical University, Shandong Academy of Medical Sciences, Shandong, Taian, 271000, China ^aEmergency Department of Shandong Provincial Hospital, Affiliated to Shandong First Medical University, Shandong Academy of Medical Sciences, Shandong, Jinan, 250021, China ^cSchool of Clinical and Basic Medical Sciences, Shandong First Medical University, Shandong Academy of Medical Sciences, Shandong, Jinan, 250117, China ^bSchool of Laboratory Animal, Shandong Laboratory Animal Center, Shandong First Medical University, Shandong Academy of Medical Sciences, Shandong, Jinan, 250117, China ^eSchool of Pharmacy, Shandong First Medical University, Shandong Academy of Medical Sciences, Shandong, Jinan, 250117, China

关键词: atherosclerosis lipoprotein phospholipid transfer protein plaque stability Profurin

摘要: Aim To investigate the effect of adenovirus -mediated Profurin expression on the plaque stability of ApoEmice. Methods ApoEmice were fed with high-fat diet for 8 weeks, and then treated with ADV-mediated PF intervention, followed by high-fat diet for 4 weeks. Aortic roots were isolated for atherosclerotic plaque area analysis and immunohistochemical analysis. Plasma phospholipid transfer protein activity was detected by fluorescence donor essay, plasma total cholesterol and triglyceride were...更多; Aim To investigate the effect of adenovirus -mediated Profurin expression on the plaque stability of ApoEmice. Methods ApoEmice were fed with high-fat diet for 8 weeks, and then treated with ADV-mediated PF intervention, followed by high-fat diet for 4 weeks. Aortic roots were isolated for atherosclerotic plaque area analysis and immunohistochemical analysis. Plasma phospholipid transfer protein activity was detected by fluorescence donor essay, plasma total cholesterol and triglyceride were measured by enzyme assay kits, and fast protein liquid chromatography was used for lipoprotein profile analysis. Results Compared with the control group, the plasma TC and TG levels, PLTP activity and circulating tumor necrosis factor-α and interleukin-6 levels in ADV-PF group were significantly decreased (Pmice.收起

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