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作者

Mengyang Cong Wen Li Yang Liu Jing Bi Xiaokun Wang Xueqiao Yang Zihan Zhang Xiaoxin Zhang Ya-Nan Zhao Rui Zhao Jianfeng Qiu

作者单位

College of Mechanical and Electronic Engineering，Shandong Agricultural University，Tai’an，China；School of Radiology，Shandong First Medical University & Shandong Academy of Medical Sciences，Tai’an，China；School of Radiology，Shandong First Medical University & Shandong Academy of Medical Sciences，Tai’an，China；School of Radiology，Shandong First Medical University & Shandong Academy of Medical Sciences，Tai’an，China；School of Radiology，Shandong First Medical University & Shandong Academy of Medical Sciences，Tai’an，China；School of Radiology，Shandong First Medical University & Shandong Academy of Medical Sciences，Tai’an，China；School of Radiology，Shandong First Medical University & Shandong Academy of Medical Sciences，Tai’an，China；School of Radiology，Shandong First Medical University & Shandong Academy of Medical Sciences，Tai’an，China；School of Radiology，Shandong First Medical University & Shandong Academy of Medical Sciences，Tai’an，China；School of Radiology，Shandong First Medical University & Shandong Academy of Medical Sciences，Tai’an，China；Department of Nuclear Medicine，The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital，Jinan，China；Science and Technology Innovation Center，Shandong First Medical University & Shandong Academy of Medical Sciences，Jinan，China；School of Radiology，Shandong First Medical University & Shandong Academy of Medical Sciences，Tai’an，China；Center for Medical Engineer Technology Research，Shandong First Medical University & Shandong Academy of Medical Sciences，Tai’an，China

刊名

定量影像学

年份

2023

卷号

第13卷

期号

第12期

页码

8768-8786

关键词

Terahertz (THz) image breast brain skin cancer

摘要

Background and Objective Terahertz imaging has wide applications in biomedical research due to its properties, such as non-ionizing, non-invasive and distinctive spectral fingerprints. Over the past 6 years, the application of THz imaging in tumor tissue has made encouraging progress. However, due to the strong absorption of THz by water, the large size, high cost, and low sensitivity of THz devices, it is still difficult to be widely used in clinical practice. This paper provides ideas for res...更多

Background and Objective Terahertz imaging has wide applications in biomedical research due to its properties, such as non-ionizing, non-invasive and distinctive spectral fingerprints. Over the past 6 years, the application of THz imaging in tumor tissue has made encouraging progress. However, due to the strong absorption of THz by water, the large size, high cost, and low sensitivity of THz devices, it is still difficult to be widely used in clinical practice. This paper provides ideas for researchers and promotes the development of THz imaging in clinical research. Methods The literature search was conducted in the Web of Science and PubMed databases using the keywords “Terahertz imaging”, “Breast”, “Brain”, “Skin” and “Cancer”. A total of 94 English language articles from 1 January, 2017 to 30 December, 2022 were reviewed. Key Content and Findings In this review, we briefly introduced the recent advances in THz near-field imaging, single-pixel imaging and real-time imaging, the applications of THz imaging for detecting breast, brain and skin tissues in the last 6 years were reviewed, and the advantages and existing challenges were identified. It is necessary to combine machine learning and metamaterials to develop real-time THz devices with small size, low cost and high sensitivity that can be widely used in clinical practice. More powerful THz detectors can be developed by combining graphene, designing structures and other methods to improve the sensitivity of the devices and obtain more accurate information. Establishing a THz database is one of the important methods to improve the repeatability and accuracy of imaging results. Conclusions THz technology is an effective method for tumor imaging. We believe that with the joint efforts of researchers and clinicians, accurate, real-time, and safe THz imaging will be widely applied in clinical practice in the future.收起

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