获取途径

作者

Li, Changgui Lu, Jie Lyu, Zhaohui Chen, Haibing Su, Benli Ban, Bo Mao, Jianhua Liu, Ping Cheng, Zhifeng Zhu, Jun Wan, Naijun Chen, Xiaobo Gong, Chunxiu Ye, Peiyu Sun, Mingshu Sun, Wenyan Zhang, Hui Yin, Han Jiang, Xiaoyun Wang, Qing Chen, Yaolong Lin, Hsiao-Yi Mi, Jie Zhao, Jiajun

作者单位

^eThe Second Hospital of Dalian Medical University, Dalian, China ^rDivision of Allergy Immunology and Rheumatology, Cheng-Hsin General Hospital, National Yang Ming Chiao Tung University, Taibei, Taiwan ^oThe First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China ^lCapital Center for Children's Health, Capital Medical University, Beijing, China ^hThe Second Affiliated Hospital, School of Medicine, The Chinese University of Hong Kong, Shenzhen & Longgang District People's Hospital of Shenzhen, Shenzhen, China ^mCenter for Non-Communicable Disease Management, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China ^bThe Affiliated Xiang'an Hospital of Xiamen University, Fujian, Xiamen, China ^jShenzhen Municipal Bao'an District Hospital, Shenzhen, China ^gChildren Hospital of Zhejiang University School of Medicine & Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou, China ^sShandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China ^fThe Affiliated Hospital of Jining Medical University, Jining, China ⁱThe Fourth Affiliated Hospital of Harbin Medical University, Harbin, China ^kBeijing Jishuitan Hospital, Capital Medical University, Beijing, China ^qResearch Unit of Evidence-Based Evaluation and Guidelines, Chinese Academy of Medical Sciences (2021RU017), School of Basic Medical Sciences, Lanzhou University, Lanzhou, China ^pSino Japanese Friendship Hospital of Jilin University, Changchun, China ^dShanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China ⁿThe Affiliated Zhongda Hospital of Southeast University, Nanjing, China ^aShandong Provincial Clinical Research Center for Immune Diseases and Gout, The Affiliated Hospital of Qingdao University, Qingdao, China ^cThe First Medical Center of Chinese PLA General Hospital, Beijing, China

刊名

International Journal of Rheumatic Diseases

年份

2025

卷号

Vol.28 No.7

ISSN

1756-1841

关键词

adolescents consensus gout hyperuricemia management

摘要

Background: In response to the increasing global prevalence of gout, there is a concerning shift towards a younger demographic, with China at the forefront of this trend. Hyperuricemia, a central factor in the pathogenesis of gout, is becoming increasingly common among adolescents, particularly males, and is associated with various health risks, including joint pain, CKD, metabolic disorders, and premature death. Despite the seriousness of this issue, there is a lack of specific guidelines addre...更多

Background: In response to the increasing global prevalence of gout, there is a concerning shift towards a younger demographic, with China at the forefront of this trend. Hyperuricemia, a central factor in the pathogenesis of gout, is becoming increasingly common among adolescents, particularly males, and is associated with various health risks, including joint pain, CKD, metabolic disorders, and premature death. Despite the seriousness of this issue, there is a lack of specific guidelines addressing adolescent and hyperuricemia gout management. Methods: The working comprising 26 clinician pediatricians, rheumatologists, and endocrinologists, all experienced in the clinical presentation and management of gout and hyperuricemia, was convened to develop a consensus. A systematic literature search was conducted in PubMed, the Cochrane Library, and EMBASE published from 1 January 1960 to 31 May 2024. Two rounds of Delphi surveys for each recommendation were conducted among all group members via electronic questionnaire. Results: Adolescent-onset gout is characterized by a pronounced genetic predisposition and distinct environmental influences, with a significant number of cases reporting a positive family history. We issued three consensus statements with five recommendations including the criteria, the urate-lowering treatment, and flare therapy principles for hyperuricemia and gout in adolescents. Conclusions: This consensus statement comprehensively delves into the critical clinical challenges associated with gout and hyperuricemia in the adolescent population, emphasizing the pressing requirement for improved detection and management strategies to support a demographic that may be underserved by the healthcare system.收起

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