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作者

Xin Wang, Xin Liu, Qiu Zi Zhong, Yun Peng Wu, Tao Wu, Yong Wen Song, Bo Chen, Hao Jing, Yuan Tang, Jing Jin, Yue Ping Liu, Hui Fang, Ning Ning Lu, Ning Li, Yi Rui Zhai, Wen Wen Zhang, Yong Yang, Shu Lian Wang, Shu Nan Qi, Ye Xiong Li

作者单位

Affiliations ¹ Department of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Collaborative Innovation Center for Cancer Medicine, Beijing 100021, China. ² Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan 250117, Shandong, China. ³ These authors contributed equally to the work. ⁴ Beijing Hospital, National Geriatric Medical Center, Beijing, China. ⁵ Affiliated Hospital of Guizhou Medical University, Guizhou Cancer Hospital, Guiyang, Guizhou, China. ⁶ Department of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital and Shenzhen Hospital, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Shenzhen 518116, China. ⁷ Department of Radiation Oncology, Fujian Medical University Union Hospital, Fuzhou, Fujian, China.

刊名

Journal of hematology

年份

2026

卷号

Vol.15 No.1

页码

34-44

ISSN

1927-1220

关键词

Age DLBCL Radiotherapy Relative survival.

摘要

Background: The aim of the study was to determine the interactive effect of age on overall survival and relative survival benefits of radiotherapy in early-stage diffuse large B-cell lymphoma . Methods: Data for 10,841 adults with early-stage DLBCL from the Surveillance, Epidemiology, and End Results database between 2002 and 2015 were retrospectively analyzed. Primary therapy was classified as combined-modality treatment and chemotherapy alone . Inverse probability of treatment weighting wa...更多

Background: The aim of the study was to determine the interactive effect of age on overall survival and relative survival benefits of radiotherapy in early-stage diffuse large B-cell lymphoma . Methods: Data for 10,841 adults with early-stage DLBCL from the Surveillance, Epidemiology, and End Results database between 2002 and 2015 were retrospectively analyzed. Primary therapy was classified as combined-modality treatment and chemotherapy alone . Inverse probability of treatment weighting was used to balance covariate distribution between the treatment groups. Survival was estimated and compared using the Kaplan-Meier method and log-rank test, respectively. Age-RT interactive effect on survival was examined through Cox regression multiplicative interaction analysis. Results: Using age of 60 years as the reference, older age was an independent predictor of shorter OS in the multivariable Cox model , 1.07; 95% confidence interval , 1.06-1.07; P = 0.020) and RS , indicating greater RT benefit in young patients. A linear correlation existed between RS and OS at the treatment arm level. Conclusions: RT was associated with improved net survival across all ages, particularly for young adults. RS was a valid alternative endpoint for prognostication and benefit evaluation.收起

文献类型

期刊