Research progress on the role of butyrylation modification in malignant tumors.

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关键词: butyrylation malignant tumor post-translational modification 丁酰化恶性肿瘤翻译后修饰

摘要: Butyrylation , as an important post-translational modification of proteins, precisely regulates various biological behaviors of tumor cells by modulating the structure and function of proteins. Abnormal butyrylation promotes tumor cell proliferation and migration by regulating protein stability, enzyme activity, cell signaling pathways, chromatin structure and gene expression, and further participates in tumor occurrence and development. This review focuses on the role of butyrylation modificat...更多; Butyrylation , as an important post-translational modification of proteins, precisely regulates various biological behaviors of tumor cells by modulating the structure and function of proteins. Abnormal butyrylation promotes tumor cell proliferation and migration by regulating protein stability, enzyme activity, cell signaling pathways, chromatin structure and gene expression, and further participates in tumor occurrence and development. This review focuses on the role of butyrylation modification in the occurrence and development of various hu-man tumors, aiming to summarize the research progress of butyrylation modification in the field of tumors, and to provide new directions for tumor treatment through the intervention strategies of butyrylation modification.收起

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