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作者

Yuhan Zhang Baoli Zhou Jiacheng Shi Mengbin Ding Xue Yuan Ruiyan Li Yijing Zhang Runtan Li Li Wang Yong Kang Mingjie Kuang Shuquan Zhang Xiaoyuan Ji

作者单位

⁷Tianjin NanKai Hospital, Tianjin, 300100, China ⁴Tianjin the First Hospital, Tianjin, 300232, China ⁸Tianjin Medical University NanKai Hospital, Tianjin, 300100, China ⁶Integrated Chinese and Western Medicine Hospital, Tianjin University, Tianjin, 300100, China ²State Key Laboratory of Advanced Medical Materials and Devices, Tianjin, 300072, China ³Yuhan Zhang and Baoli Zhou contributed equally to this work. ¹Academy of Medical Engineering and Translational Medicine, Medical College, Tianjin University, Tianjin, 300072, China ⁵Department of Orthopedics, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, 250021, China

刊名

Chemical Engineering Journal

年份

2026

卷号

Vol.532

页码

174598

ISSN

1385-8947

摘要

Effective therapy of bone metastatic cancer requires simultaneous tumor suppression and bone repair, for which site-specific, demand-driven electrical stimulation is conceptually attractive. However, most current systems remain externally powered with limited in situ responsiveness, precluding precise and durable regulation in vivo. Here, we developed an implantable, self-powered, and adaptive electrical stimulation platform based on a hybrid piezoelectric-triboelectric nanogenerator that auton...更多

Effective therapy of bone metastatic cancer requires simultaneous tumor suppression and bone repair, for which site-specific, demand-driven electrical stimulation is conceptually attractive. However, most current systems remain externally powered with limited in situ responsiveness, precluding precise and durable regulation in vivo. Here, we developed an implantable, self-powered, and adaptive electrical stimulation platform based on a hybrid piezoelectric-triboelectric nanogenerator that autonomously responds to physiological motion to generate tunable electrical outputs, enabling bifunctional therapy spanning tumor inhibition and bone regeneration. The PTNG was fabricated via 3D printing and assembled into a sandwich architecture integrating piezoelectric PLA with triboelectric PDMS, allowing pressure-dependent modulation of electrical output. Under low-intensity stimulation, the PTNG produced low voltages that markedly reduced 4T1 tumor cell viability, demonstrating voltage-dependent selectivity between osteogenic and malignant cells. When implanted at metastatic bone lesions, motion-induced skin friction generated high-intensity stimulation , disrupting microtubule architecture, inducing cell-cycle arrest, and triggering immunogenic cell death through a reactive oxygen species -endoplasmic reticulum stress-damage-associated molecular pattern signaling axis, thereby restraining tumor progression. In contrast, implantation at bone-defect sites yielded weaker electrical cues due to reduced mechanical inputs, establishing a pro-regenerative microenvironment that supported osteoblast proliferation and differentiation and accelerated bone repair. Collectively, this work introduces a wireless, self-regulating electrotherapy platform that enables site-adaptive stimulation with dual therapeutic outcomes, providing a clinically translatable strategy for bone metastases.收起

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