Multi-Activity Nanozyme-Integrated Scaffolds: Harnessing Synergistic Enzyme-like Effects for Complete Treatment of Infected Bone Defects

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作者: Zhengguang Wang Qian Wang Kaixi Liu Xing Peng Jiedong Wang Shengxin Zeng Kangchun Wang Shuai Han Shilong Su Jing Ye Chaoxin Wang Yuanyu Hu Zeqi Ren Caimei Wang Xiaolin Ma Jiajia Zheng Yubao Lu Peng Wen Yufeng Zheng Lizeng Gao Yun Tian Bingchuan Liu

作者单位: ¹²Department of Laboratory Medicine, Peking University Third Hospital, Beijing 100191, China ⁵Tribology Research Institute, School of Mechanical Engineering, Southwest Jiaotong University, Chengdu 610031, China ⁷School of Medicine, Southeast University, Nanjing 210009, China ¹⁴Department of Mechanical Engineering, Tsinghua University, Beijing 100084, China ³Graduate School of University of Chinese Academy of Sciences, Beijing 100049, China ¹¹Beijing AKEC Medical Co., Ltd., Beijing 102200, China ¹⁰School of Materials Science and Engineering, Peking University, Beijing 100871, China ⁴Department of Anesthesiology, Peking University Third Hospital, Beijing 100191, China ⁶Department of Orthopedics, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong 250021, China ⁹Department of Orthopaedic Surgery, the First Affiliated Hospital, Fujian Medical University, Fuzhou 35000, China ¹Department of Orthopedics, Peking University Third Hospital, 100191 Beijing, China ²State Key Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China ⁸Department of Plastic and Cosmetic Surgery, Shenzhen University General Hospital, Shenzhen 518055, China ¹³Department of Spine Surgery, The Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong 510630, China

关键词: multiple enzyme-like activities ferroptosis angiogenesis osteogenesis hydrogel

摘要: Infected bone defects pose a major clinical challenge because they typically involve severe infection, poor vascularization, and bone loss. Existing implant materials lack integrated functionality for long-term infection control and tissue regeneration. Here, a multifunctional nanozyme platform consisting of a 3D-printed titanium scaffold functionalized with an iron sulfide multiactivity nanozyme -modified hydrogel is introduced. The platform leverages synergistic peroxidase-like, myeloperoxidas...更多; Infected bone defects pose a major clinical challenge because they typically involve severe infection, poor vascularization, and bone loss. Existing implant materials lack integrated functionality for long-term infection control and tissue regeneration. Here, a multifunctional nanozyme platform consisting of a 3D-printed titanium scaffold functionalized with an iron sulfide multiactivity nanozyme -modified hydrogel is introduced. The platform leverages synergistic peroxidase-like, myeloperoxidase-like, and glutathione peroxidase -like activities, alongside the controlled release of Fe and polysulfides. This dual mechanism induces ferroptosis-like bacterial death while concurrently promoting angiogenesis and osteogenesis. The platform represents a promising nanozyme-based strategy for the treatment of infected bone defects.收起

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