Affiliations 1 Department of Cardiology, Shandong Medicine and Health Key Laboratory of Cardiac Electrophysiology and Arrhythmia, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong First Medical University, Jinan, Shandong, 250012, China. 2 Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, 830054, P. R. China. 3 Department of Cardiology, Shandong Medicine and Health Key Laboratory of Cardiac Electrophysiology and Arrhythmia, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong First Medical University, Jinan, Shandong, 250012, China. abrahamzhangy@16com.
Background: The ratio of uric acid to high-density lipoprotein cholesterol is a novel comprehensive indicator related to dyslipidemia. However, the association between UHR and coronary artery disease risk in patients with chronic kidney disease remains unclear. Methods: After matching based on age and gender propensity scores, 2124 subjects were included and divided into the CKD group and the non-CKD group . The predictive performance of UHR for CAD was evaluated by the area under the curve ...更多
Background: The ratio of uric acid to high-density lipoprotein cholesterol is a novel comprehensive indicator related to dyslipidemia. However, the association between UHR and coronary artery disease risk in patients with chronic kidney disease remains unclear. Methods: After matching based on age and gender propensity scores, 2124 subjects were included and divided into the CKD group and the non-CKD group . The predictive performance of UHR for CAD was evaluated by the area under the curve , and the independent association between UHR and the risk of CAD onset was analyzed using a multivariate logistic regression model. The correlation and dose-response relationship between the ratio of uric acid to high-density lipoprotein cholesterol and the risk of CAD were analyzed using LOESS fitting and restricted cubic spline analysis. Results: After matching, the multiple lipid-related indices , Remnant Cholesterol , Atherogenic Index , Atherogenic Index of Plasma , Triglyceride Glucose Index , Lipoprotein Composite Index , Triglyceride to High-Density Lipoprotein Cholesterol Ratio , Total Cholesterol to High-Density Lipoprotein Cholesterol Ratio , Low-Density Lipoprotein Cholesterol to High-Density Lipoprotein Cholesterol Ratio , UHR) in the CKD group were significantly higher than those in the non-CKD group. The AUC analysis showed that HDL-C, AIP, TG/HDL-C, and UHR had strong predictive performance in the overall cohort and the non-CKD group, while in the CKD group, HDL-C, AI, and TC/HDL-C are better predictive indicators. After adjusting for all confounding factors, multivariate regression analysis revealed that HDL-C, apolipoprotein A-1 , and the APOA-1/APOB ratio were independent protective factors for CAD in the entire cohort. Among them, the protective effect of HDL-C was the most stable (overall population aOR = 0.26, 95% CI: 0.17-0.39, p 0.5, r = 0.2, p 0.41 in CKD patients. Conclusions: UHR is an independent risk factor for coronary heart disease, with higher adjusted OR values and more significant independent risk effects in non-CKD populations.收起
