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作者

Zhiyuan Gong, Qi Hu, Zahra Sabagh, Tianyu Liang, Cheng He

作者单位

com. ⁴ Emergency and Critical Care Center, Department of Nursing, Intensive Care Unit, Zhejiang Provincial People's Hospital (Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, China. hchchhc0823@16 Affiliations ¹ Department of Nursing, The Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, No. N1, Shangcheng Avenue, Yiwu, 322000, Zhejiang, China. ² The Second Affiliated Hospital of Shandong First Medical University, Tai'an, 271000, Shandong, China. ³ Emergency and Critical Care Center, Intensive Care Unit, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, Zhejiang, China. liangtianyu1111@16 com.

刊名

Journal of health, population, and nutrition

年份

2025

卷号

Vol.45 No.1

页码

36

ISSN

2072-1315

关键词

Bone Gut microbiota Meta-analysis Osteoprosis Probiotic.

摘要

Background: Probiotic/synbiotic, have been proposed as a supplement to improve bone health markers. However, findings evidence remains inconsistent. This meta-analysis aimed to assess the effects of Probiotic/synbiotic supplementation on osteoporosis. Methods: A systematic search was carried out in PubMed, Embase, Web of Science, and the Cochrane Library up to June 2025 to evaluate the efficacy of probiotic or synbiotic supplementation for osteoporosis. Data were pooled using a random-effects mo...更多

Background: Probiotic/synbiotic, have been proposed as a supplement to improve bone health markers. However, findings evidence remains inconsistent. This meta-analysis aimed to assess the effects of Probiotic/synbiotic supplementation on osteoporosis. Methods: A systematic search was carried out in PubMed, Embase, Web of Science, and the Cochrane Library up to June 2025 to evaluate the efficacy of probiotic or synbiotic supplementation for osteoporosis. Data were pooled using a random-effects model to calculate standardized mean differences and 95% Confidence intervals . Results: Ten studies were included in this meta-analysis. Probiotic/synbiotic supplementation significantly decreased PTH levels , and increased lumbar spine BMD . However, probiotic/synbiotic supplementation did not significantly affect BMD of the total hip , C-terminal telopeptide , osteocalcin , alkaline phosphatase , and osteoprotegerin . Begg's test revealed no significant publication bias. Conclusions: The current meta-analysis revealed that probiotic/synbiotic supplementation beneficial effect on PTH, and lumbar spine BMD. No favorable effect of probiotic/synbiotic supplementation on BMD of the total hip, CTX, osteocalcin, ALP, and osteoprotegerin was observed.收起

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