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作者

Jiaqi Peng Xintian Wang Jiamin Wang Dongshan Zhu Xiaojie Sun & …Xuemei Zhen

作者单位

⁸Center for Cancer control and Policy Research, Shandong University, Jinan, 250012, China ³Department of Human Resources, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250021, China ⁵Center for Clinical Epidemiology and Evidence-Based Medicine, Shandong University, Jinan, 250012, China ²School of Fine Arts, Shandong University, Jinan, 250101, China ⁷NHC Key Lab of Health Economics and Policy Research, Shandong University, Jinan, 250012, China ⁶Department of Social Medicine and Health Management, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, 250012, China ⁴Department of Epidemiology, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, 250012, China ¹Department of Operations and Performance, The Tenth Affiliated Hospital, Southern Medical University (Dongguan People’s Hospital), Dongguan, 523059, China

刊名

BMC Cancer

关键词

Antibiotics use Early life Cancers UK Biobank Risk

摘要

Background There is little evidence about the associations of long-term or recurrent antibiotics use during early life with cancer risk. Methods Our study aimed to assess the associations via Cox proportional hazards regression, using data from the UK Biobank . The main outcomes were the incidence of adult kidney cancer and sex-specific cancers, classified according to International Classification of Diseases, 10th revision . LRAU during early life was self-reported. Results 136,011 partic...更多

Background There is little evidence about the associations of long-term or recurrent antibiotics use during early life with cancer risk. Methods Our study aimed to assess the associations via Cox proportional hazards regression, using data from the UK Biobank . The main outcomes were the incidence of adult kidney cancer and sex-specific cancers, classified according to International Classification of Diseases, 10th revision . LRAU during early life was self-reported. Results 136,011 participants were included in the study, with a mean follow-up of 7.5 years . Among participants with LRAU during early life, a higher proportion were women . Among all participants, LRAU during early life was associated with a higher risk of kidney cancer in the fully adjusted model . No significant associations were observed between LRAU during early life and other non-sex-specific cancers. Sex-stratified analysis revealed that LRAU during early life was associated with an increased risk of kidney cancer , bladder cancer and breast cancer in females. For males, LRAU during early life was associated with an increased risk of esophageal cancer . After stratifying the analyses by age at menarche, LRAU during early life was associated with an increased risk of breast cancer among women with menarche after age 12 years , but the interaction effect was not statistically significant . Conclusions This study provides evidence suggesting that LRAU during early life may be associated with an increased risk of kidney cancer, bladder and breast cancer in adult females, and esophageal cancer in adult males.收起

文献类型

期刊