Pharmacy College, Zhejiang University of Technology, Hangzhou, ChinaCollege of Material, Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou, ChinaPharmacy College, Taishan Medical University, Tai'an, China
A highly efficient and practical procedure for palladium‐catalyzed direct thioetherification of quinolone derivatives with diaryl disulfides through decarboxylative C−S coupling has been established. The reaction could proceed smoothly under air in the presence of Pd(OAc)2 and Ag2CO3 in DMSO. This protocol provides an appealing alternative to existing approaches to construct aryl sulfides of quinolone derivatives, which may be used as key intermediates in the synthesis of drug candidates. A pall...更多
A highly efficient and practical procedure for palladium‐catalyzed direct thioetherification of quinolone derivatives with diaryl disulfides through decarboxylative C−S coupling has been established. The reaction could proceed smoothly under air in the presence of Pd(OAc)2 and Ag2CO3 in DMSO. This protocol provides an appealing alternative to existing approaches to construct aryl sulfides of quinolone derivatives, which may be used as key intermediates in the synthesis of drug candidates. A palladium‐catalyzed thioetherification of quinolone derivatives with diaryl disulfides through a decarboxylative C−S cross‐coupling reaction has been developed. The reaction shows good compatibility with a broad range of functional groups and more than 25 examples of novel functionalized quinolone derivatives were obtained in good yields. This protocol provides an appealing alternative to existing approaches to construct aryl sulfides of quinolone derivatives, which may be used as key intermediates in the synthesis of drug candidates.收起
