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作者

Dr. Chengcai Xia Dr. Zhenjiang Wei Dr. Yong Yang Dr. Wenbo Yu Dr. Hanxiao Liao Dr. Chao Shen Prof. Pengfei Zhang

作者单位

Pharmacy College, Zhejiang University of Technology, Hangzhou, China College of Material, Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou, China Pharmacy College, Taishan Medical University, Tai'an, China

刊名

Chemistry - An Asian Journal

年份

2016

卷号

Vol.11 No.3

页码

360-366

ISSN

1861-471X

关键词

C−S coupling decarboxylative palladium quinolone derivatives thioetherification

摘要

A highly efficient and practical procedure for palladium‐catalyzed direct thioetherification of quinolone derivatives with diaryl disulfides through decarboxylative C−S coupling has been established. The reaction could proceed smoothly under air in the presence of Pd(OAc)2 and Ag2CO3 in DMSO. This protocol provides an appealing alternative to existing approaches to construct aryl sulfides of quinolone derivatives, which may be used as key intermediates in the synthesis of drug candidates. A pall...更多

A highly efficient and practical procedure for palladium‐catalyzed direct thioetherification of quinolone derivatives with diaryl disulfides through decarboxylative C−S coupling has been established. The reaction could proceed smoothly under air in the presence of Pd(OAc)2 and Ag2CO3 in DMSO. This protocol provides an appealing alternative to existing approaches to construct aryl sulfides of quinolone derivatives, which may be used as key intermediates in the synthesis of drug candidates. A palladium‐catalyzed thioetherification of quinolone derivatives with diaryl disulfides through a decarboxylative C−S cross‐coupling reaction has been developed. The reaction shows good compatibility with a broad range of functional groups and more than 25 examples of novel functionalized quinolone derivatives were obtained in good yields. This protocol provides an appealing alternative to existing approaches to construct aryl sulfides of quinolone derivatives, which may be used as key intermediates in the synthesis of drug candidates.收起

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