MOE Key Laboratory of Laser Life Science &Institute of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou 510631, China. xlli@scnu.edu.cn chentsh@scnu.edu.cn. State Key Laboratory of Environment-friendly Energy Materials, Southwest University of Science and Technology, Mianyang 621010, China. College of Life Science, Taishan Medical University, Taian 271016, China.
刊名
Physical chemistry chemical physics
年份
2018
ISSN
1463-9084
分类号
541
摘要
Nanostructure arrays have drawn much attention and are promising as new biomaterials in the field of biomedicine. In recent years, numerous experimental studies on the cell behavior of nanostructured arrays have been published, describing a wide variety of experimental results. But there are only a few theoretical analyses that elucidate the mechanisms of interactions between cells and nanostructures. Here we present a quantitative thermodynamic model to elucidate the effects of surface topogra...更多
Nanostructure arrays have drawn much attention and are promising as new biomaterials in the field of biomedicine. In recent years, numerous experimental studies on the cell behavior of nanostructured arrays have been published, describing a wide variety of experimental results. But there are only a few theoretical analyses that elucidate the mechanisms of interactions between cells and nanostructures. Here we present a quantitative thermodynamic model to elucidate the effects of surface topography of nanostructure arrays on cell adhesion. Based on the established model, we studied the equilibrium state of cell adhesion by analyzing the change in free energy during the adhesion process. Theoretical results showed that cell adhesion mode is actually determined by the balance between adhesion energy and deformation energy of the cell membrane. According to the calculated results, a phase diagram of the cell adhesion has been constructed, which can clarify the interrelated effects of the radius and surface distribution density of nanopillars. We can identify the relation between the surface topography of nanostructure arrays and the cell adhesion mode from the phase.收起
