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作者

Zhou, Jing Zhang, Xiaowei Sun, Jizheng Dang, Zechun Li, Jinqi Li, Xinlei Chen, Tongsheng

作者单位

Taishan Med Univ, Coll Life Sci, Tai An 271016, Shandong, Peoples R China Southwest Univ Sci & Technol, State Key Lab Environm Friendly Energy Mat, Mianyang 621010, Peoples R China South China Normal Univ, Coll Biophoton, Inst Laser Life Sci, Guangzhou 510631, Guangdong, Peoples R China South China Normal Univ, Coll Biophoton, MOE Key Lab Laser Life Sci, Guangzhou 510631, Guangdong, Peoples R China

刊名

PHYSICAL CHEMISTRY CHEMICAL PHYSICS

年份

2018

卷号

Vol.20 No.35

页码

22946-22951

ISSN

1463-9076

分类号

541

摘要

Nanostructure arrays have drawn much attention and are promising as new biomaterials in the field of biomedicine. In recent years, numerous experimental studies on the cell behavior of nanostructured arrays have been published, describing a wide variety of experimental results. But there are only a few theoretical analyses that elucidate the mechanisms of interactions between cells and nanostructures. Here we present a quantitative thermodynamic model to elucidate the effects of surface topogra...更多

Nanostructure arrays have drawn much attention and are promising as new biomaterials in the field of biomedicine. In recent years, numerous experimental studies on the cell behavior of nanostructured arrays have been published, describing a wide variety of experimental results. But there are only a few theoretical analyses that elucidate the mechanisms of interactions between cells and nanostructures. Here we present a quantitative thermodynamic model to elucidate the effects of surface topography of nanostructure arrays on cell adhesion. Based on the established model, we studied the equilibrium state of cell adhesion by analyzing the change in free energy during the adhesion process. Theoretical results showed that cell adhesion mode is actually determined by the balance between adhesion energy and deformation energy of the cell membrane. According to the calculated results, a phase diagram of the cell adhesion has been constructed, which can clarify the interrelated effects of the radius and surface distribution density of nanopillars. We can identify the relation between the surface topography of nanostructure arrays and the cell adhesion mode from the phase.收起

学科

【SCI学科】CHEMISTRY, PHYSICAL;PHYSICS, ATOMIC, MOLECULAR & CHEMICAL 【ESI学科】CHEMISTRY

影响因子

2016年:4.123;2015年:4.449;2014年:4.493;2013年:4.198;2012年:3.829

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