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作者

Li Juan Quan Chuansong Xie Yun Ke Changwen Nie Yifei Chen Quanjiao Hu Tao Chen Jianjun Wong Gary Wang Qianli Feng Luzhao Yu Hongjie Liu Yingxia Liu Wenjun Gao George F Liu William J Shi Weifeng Bi Yuhai

作者单位

Key Laboratory of Etiology and Epidemiology of Emerging Infectious Diseases in Shandong Universities, Taishan Medical College, Taian, Shandong, 271000, China. CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Center for Influenza Research and Early-warning (CASCIRE), Chinese Academy of Sciences, Beijing, 100101, China. National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, 102206, China. Jiangxi Provincial Center for Disease Control and Prevention, Nanchang, 330029, China. Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, 511430, China. Henan Provincial Center for Disease Control and Prevention, Zhengzhou, 450016, China. CAS Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Hubei, 430071, China. Shenzhen Key Laboratory of Pathogen and Immunity, State Key Discipline of Infectious Disease, Second Hospital Affiliated to Southern University of Science and Technology, Shenzhen Third People's Hospital, Shenzhen, 518112, China. Département de microbiologie-infectiologie et d'immunologie, Université Laval, Québec, QC, G1V 4G2, Canada. Chinese Center for Disease Control and Prevention, Beijing, 102206, China.

刊名

Transboundary and emerging diseases

年份

2018

ISSN

1865-1682

关键词

H6 subtype Low pathogenic avian influenza evolution molecular characterization reassortment

分类号

636.089

摘要

H6 subtype avian influenza virus was prevalent in poultry and could sporadically infect humans. Here, a total of 196 novel H6 AIVs isolated from poultry in eight provinces of China from 2014 to 2016 were phylogenetically characterized. Our analysis revealed that they could be divided into two clades in the Asian H6 HA lineage, A/wild duck/Shantou/2853/2003 and A/duck/Shantou/339/2000 , in which ST2853-like strains predominate. These novel strains belonged to the H6N6 , H6N2 and H6N3 subtyp...更多

H6 subtype avian influenza virus was prevalent in poultry and could sporadically infect humans. Here, a total of 196 novel H6 AIVs isolated from poultry in eight provinces of China from 2014 to 2016 were phylogenetically characterized. Our analysis revealed that they could be divided into two clades in the Asian H6 HA lineage, A/wild duck/Shantou/2853/2003 and A/duck/Shantou/339/2000 , in which ST2853-like strains predominate. These novel strains belonged to the H6N6 , H6N2 and H6N3 subtypes, which could be classified into 36 genotypes including 12 novel genotypes described in this study. In particular, several strains possessed the V190 and S228 mutations in HA , which is critical for human receptor binding and identical to the human-derived strain A/Taiwan/2/2013. Furthermore, 10.3% of the H6N6 isolates possessed the N6-∆11b deletion. In summary, we describe phylogenetic and molecular characterizations of H6 AIVs in southern China and highlight the constant prevalence of H6 AIVs in poultry as well as adaptation to mammalian hosts. This article is protected by copyright. All rights reserved.收起

学科

【SCI学科】VETERINARY SCIENCES;INFECTIOUS DISEASES 【ESI学科】PLANT & ANIMAL SCIENCE

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