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作者

Liu, G Li, DC Li, PP Li, RR Chen, SY

作者单位

Affiliated Hosp Taishan Med Univ, Dept Paediat, Tai An 271000, Shandong, Peoples R China

刊名

Tropical Journal of Pharmaceutical Research

年份

2016

卷号

Vol.15 No.7

页码

1361-1368

ISSN

1596-5996

关键词

Pediatric patient, Methotrexate nanoparticle, Inflammatory bowel disease, Azathioprine Full Text: EMAIL FREE FULL TEXT DOWNLOAD FULL TEXT Article Metrics Metrics Loading ... _{Metrics powered by PLOS ALM options = { almStatsJson: $.parseJSON(\'[{\"publication_date\":\"2016-08-11T00:00:00+02:00\",\"doi\":\"\",\"title\":\"Methotrexate nanoparticle delivery system for treatment of inflammatory bowel disease in pediatric patients\",\"sources\":[]}]\'), additionalStatsJson: $.parseJSON(\'{\"name\":\"ojsViews\",\"display_name\":\"This journal\",\"events_url\":null,\"metrics\":{\"pdf\":0,\"html\":0,\"shares\":null,\"groups\":null,\"comments\":null,\"likes\":null,\"citations\":0},\"by_day\":null,\"by_month\":null,\"by_year\":null}\'), baseUrl: \'http://pkp-alm.lib.sfu.ca/\', minItemsToShowGraph: { minEventsForYearly: 0, minEventsForMonthly: 0, minEventsForDaily: 0, minYearsForYearly: 0, minMonthsForMonthly: 0, minDaysForDaily: 0 }, hasIcon: [\'wikipedia\', \'scienceseeker\', \'researchblogging\', \'pubmed\', \'nature\', \'mendeley\', \'facebook\', \'crossref\', \'citeulike\', \'ojsViews\'], categories: [{ name: "html", display_name: \'HTML Views.\', tooltip_text: \'Total number of HTML page views for this article. These views are recorded directly within the system itself. Overall monthly view counts may also be available.\' }, { name: "pdf", display_name: \'PDF Views.\', tooltip_text: \'Total number of PDF views and downloads for this article. These views are recorded directly within the system itself. Overall monthly view counts may also be available.\' }, { name: "likes", display_name: \'Likes\', tooltip_text: \'Likes found in social networks such as Facebook.\' }, { name: "shares", display_name: \'Shares\', tooltip_text: \'Shares or bookmarks in social networks such as Facebook, CiteULike and Mendeley. In most cases, clicking on the number of shares will take you to a listing in the network itself.\' }, { name: "citations", display_name: \'Citations\', tooltip_text: \'Citations of this article found in CrossRef, PubMed and Wikipedia. In most cases, clicking on the citation count will take you to a listing in the referencing service itself.\' }], vizDiv: "#alm" } // Import JQuery 1.10 version, needed for the tooltip plugin // that we use below. jQuery.noConflict puts the old $ back. $.getScript(\'http://www.ajol.info/plugins/generic/alm/js/jquery-1.10.2.min.js\', function() { $.getScript(\'http://www.ajol.info/plugins/generic/alm/js/bootstrap.tooltip.min.js\', function() { // Assign the last inserted JQuery version to a new variable, to avoid // conflicts with the current version in $ variable. options.jQuery = $} var almviz = new AlmViz(options) almviz.initViz() jQuery.noConflict(true) }) }) (function(i,s,o,g,r,a,m){i[\'GoogleAnalyticsObject\']=r i[r]=i[r]||function(){ (i[r].q=i[r].q||[]).push(arguments)},i[r].l=1*new Date() a=s.createElement(o), m=s.getElementsByTagName(o)[0] a.async=1 a.src=g m.parentNode.insertBefore(a,m) })(window,document,\'script\',\'//www.google-analytics.com/analytics.js\',\'ga\') ga(\'create\', \'UA-267014-1\', \'auto\') ga(\'send\', \'pageview\')

分类号

615.1

摘要

Purpose: To evaluate the efficacy and safety of methotrexate (MTX) nanoparticles in pediatric patients with inflammatory bowel disease (IBD).Methods: In this randomized, open-label clinical study, 28 pediatric patients with moderate to severe IBD were randomly assigned to treatment (MTX nanoparticles,15 mg/week) or control (azathioprine, AZA, 2 mg/kg/day) group. Nanoparticles were synthesized by adding calcium chloride to sodium alginate solution containing MTX, and was further treated with poly...更多

Purpose: To evaluate the efficacy and safety of methotrexate (MTX) nanoparticles in pediatric patients with inflammatory bowel disease (IBD).Methods: In this randomized, open-label clinical study, 28 pediatric patients with moderate to severe IBD were randomly assigned to treatment (MTX nanoparticles,15 mg/week) or control (azathioprine, AZA, 2 mg/kg/day) group. Nanoparticles were synthesized by adding calcium chloride to sodium alginate solution containing MTX, and was further treated with poly-L-lysine aqueous solution. The nanoparticles were evaluated for particle size, zeta potential and drug encapsulation efficacy. Erythrocyte sedimentation rate, C-reactive protein, aspartate aminotransferase, alanine transaminase, and disease activity scores were used to assess IBD remission.Results: Nanoparticle size, zeta potential and encapsulation efficacy were 164.4 ± 6.9 nm, -32.6 ± 3.7 mV, and 97.8 ± 4.2 %, respectively. After 12 weeks of therapy, the mean Pediatric Crohn\'s Disease Activity Index (PCDAI) scores for control and treatment groups were 22.3 ± 2.14 and 16.8 ± 1.87, respectively, while mean Pediatric Ulcerative Colitis Activity (PUCAI) Index scores were 24.3 ± 1.47 and18.7 ± 1.92, respectively. Eight patients in the treatment and five patients in the control group achieved remission. Biochemical parameters varied significantly between the groups.Conclusion: MTX nanoparticles are safe and more effective than standard first-line IBD therapy. However, further studies are required to determine the suitability of the formulation for therapeutic use.Keywords: Pediatric patient, Methotrexate nanoparticle, Inflammatory bowel disease, Azathioprine Full Text: EMAIL FREE FULL TEXT DOWNLOAD FULL TEXT Article Metrics Metrics Loading ... Metrics powered by PLOS ALM options = { almStatsJson: $.parseJSON(\'[{\\'publication_date\\':\\'2016-08-11T00:00:00+02:00\\',\\'doi\\':\\'\\',\\'title\\':\\'Methotrexate nanoparticle delivery system for treatment of inflammatory bowel disease in pediatric patients\\',\\'sources\\':[]}]\'), additionalStatsJson: $.parseJSON(\'{\\'name\\':\\'ojsViews\\',\\'display_name\\':\\'This journal\\',\\'events_url\\':null,\\'metrics\\':{\\'pdf\\':0,\\'html\\':0,\\'shares\\':null,\\'groups\\':null,\\'comments\\':null,\\'likes\\':null,\\'citations\\':0},\\'by_day\\':null,\\'by_month\\':null,\\'by_year\\':null}\'), baseUrl: \'http://pkp-alm.lib.sfu.ca/\', minItemsToShowGraph: { minEventsForYearly: 0, minEventsForMonthly: 0, minEventsForDaily: 0, minYearsForYearly: 0, minMonthsForMonthly: 0, minDaysForDaily: 0 }, hasIcon: [\'wikipedia\', \'scienceseeker\', \'researchblogging\', \'pubmed\', \'nature\', \'mendeley\', \'facebook\', \'crossref\', \'citeulike\', \'ojsViews\'], categories: [{ name: \'html\', display_name: \'HTML Views.\', tooltip_text: \'Total number of HTML page views for this article. These views are recorded directly within the system itself. Overall monthly view counts may also be available.\' }, { name: \'pdf\', display_name: \'PDF Views.\', tooltip_text: \'Total number of PDF views and downloads for this article. These views are recorded directly within the system itself. Overall monthly view counts may also be available.\' }, { name: \'likes\', display_name: \'Likes\', tooltip_text: \'Likes found in social networks such as Facebook.\' }, { name: \'shares\', display_name: \'Shares\', tooltip_text: \'Shares or bookmarks in social networks such as Facebook, CiteULike and Mendeley. In most cases, clicking on the number of shares will take you to a listing in the network itself.\' }, { name: \'citations\', display_name: \'Citations\', tooltip_text: \'Citations of this article found in CrossRef, PubMed and Wikipedia. In most cases, clicking on the citation count will take you to a listing in the referencing service itself.\' }], vizDiv: \'#alm\' } // Import JQuery 1.10 version, needed for the tooltip plugin // that we use below. jQuery.noConflict puts the old $ back. $.getScript(\'http://www.ajol.info/plugins/generic/alm/js/jquery-1.10.2.min.js\', function() { $.getScript(\'http://www.ajol.info/plugins/generic/alm/js/bootstrap.tooltip.min.js\', function() { // Assign the last inserted JQuery version to a new variable, to avoid // conflicts with the current version in $ variable. options.jQuery = $; var almviz = new AlmViz(options); almviz.initViz(); jQuery.noConflict(true); }); }); (function(i,s,o,g,r,a,m){i[\'GoogleAnalyticsObject\']=r;i[r]=i[r]||function(){ (i[r].q=i[r].q||[]).push(arguments)},i[r].l=1*new Date();a=s.createElement(o), m=s.getElementsByTagName(o)[0];a.async=1;a.src=g;m.parentNode.insertBefore(a,m) })(window,document,\'script\',\'//www.google-analytics.com/analytics.js\',\'ga\'); ga(\'create\', \'UA-267014-1\', \'auto\'); ga(\'send\', \'pageview\');收起

学科

【SCI学科】PHARMACOLOGY & PHARMACY 【ESI学科】PHARMACOLOGY & TOXICOLOGY

影响因子

2016年:0.569;2015年:0.543;2014年:0.589;2013年:0.495;2012年:0.5

文献类型

期刊

浏览量

28