Department of Endocrinology, Weihai Hospital Affiliated to Medical College of Qingdao University, No 51 Guangming road, Huancui District, 264200, Weihai, ChinaDepartment of Epidemiology and Health Statistics, Qingdao University, Qingdao, ChinaDepartment of Endocrinology and Metabolic Disease, The Affiliated Hospital of Qingdao University, Qingdao, ChinaDepartment of Endocrinology, Laiwu Hospital Affiliated to Taishan Medical College, Laiwu, China
Background: The association of serum high-density lipoprotein cholesterol with microalbuminuria in type 2 diabetes mellitus remains controversial. Therefore, a cross-sectional study was conducted on patients with T2DM to investigate the relationship of HDL-C with microalbuminuria. Methods: A total of 524 participants with T2DM were recruited in this cross-sectional study. The patients were divided into four groups according to serum HDL-C quartile. A nonparametric test was employed to assess t...更多
Background: The association of serum high-density lipoprotein cholesterol with microalbuminuria in type 2 diabetes mellitus remains controversial. Therefore, a cross-sectional study was conducted on patients with T2DM to investigate the relationship of HDL-C with microalbuminuria. Methods: A total of 524 participants with T2DM were recruited in this cross-sectional study. The patients were divided into four groups according to serum HDL-C quartile. A nonparametric test was employed to assess the relationships across quartiles with clinical parameters and demographics. Multivariate logistic regression analysis was further performed. Results: Of the 524 patients, 138 were found to have microalbuminuria by urinary albumin excretion rate determination. Serum HDL-C levels in microalbuminuria group were significantly lower than those in non-microalbuminuria group vs. 1.10 mmol/L, P = 0.002). The nonparametric test for trend showed that the prevalence of microalbuminuria was significantly reduced for subjects of the fourth quartile of HDL-C compared to the first to third quartile . Multivariate logistic regression showed that subjects within the highest quartile of HDL-C had lower odds of microalbuminuria than those within the lowest quartile of HDL-C . Conclusions: Higher levels of serum HDL-C were associated with decreased rates of microalbuminuria in T2DM patients.收起
