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作者

Ran, Zhangshen Hou, Lixia Guo, Hongxia Wang, Keqiang Li, Xiangqi

作者单位

Taishan Med Univ, Radiat Inst, Tai An, Shandong, Peoples R China Taishan Med Univ, Affiliated Hosp, Dept Clin Lab, Tai An, Shandong, Peoples R China Taishan Med Univ, Affiliated Hosp, Dept Breast Surg, Tai An, Shandong, Peoples R China Taishan Med Univ, Affiliated Hosp, Dept Phys Examinat Ctr, Tai An, Shandong, Peoples R China

刊名

INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY

年份

2018

卷号

Vol.11 No.9

页码

4264-4269

ISSN

1936-2625

关键词

Breast cancer ultrasound features VEGF COX-2 MMP-9

分类号

616.07

摘要

Objective: We wished to ascertain the relationship between expression of vascular endothelial growth factor , cyclo-oxygenase -2, and matrix metallopeptidase -9 and various features of ultrasound images in breast cancer patients. Methods: Eighty-nine breast lesions were confirmed to have BC by ultrasound, surgery and pathology. According to the Breast Imaging Reporting and Data System classification method published by the American College of Radiology, six groups were created: spiculation and ...更多

Objective: We wished to ascertain the relationship between expression of vascular endothelial growth factor , cyclo-oxygenase -2, and matrix metallopeptidase -9 and various features of ultrasound images in breast cancer patients. Methods: Eighty-nine breast lesions were confirmed to have BC by ultrasound, surgery and pathology. According to the Breast Imaging Reporting and Data System classification method published by the American College of Radiology, six groups were created: spiculation and non-Burr sign; calcification and noncalcification; vascular anomaly syndrome and non-vascular anomaly syndrome; lymph node metastasis and non-LNM. In each case, the expression of VEGF, COX-2 and MMP-9 was detected by immunohistochemistry. Results: Expression of VEGF, COX-2 and MMP-9 was higher in BC patients with the Burr sign than in those without it . Expression of VEGF, COX-2, and MMP-9 was higher in those with vascular abnormalities than in those without them , as well as in the LNM group compared with the non-LNM group . Conclusions: The high expression of VEGF, COX-2, and MMP-9 could have an influence on the Burr sign, abnormal blood vessels, and LNM in BC patients using ultrasound.收起

学科

【SCI学科】PATHOLOGY;ONCOLOGY 【ESI学科】CLINICAL MEDICINE

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