College of Medicine and Pharmaceutics, Ocean University of China, Qingdao 266003, ChinaTaishan Medical University, Taian, Shandong Province 271016, ChinaDonghai Middle Road, Qingdao 266071, Chinaa Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, NoDepartment of VIP, Affiliated Hospital of Nantong University, Nantong, Jiangsu Province 226001, China
Background: Toll-like receptor 2 represents a reasonable functional and positional candidate gene for Alzheimer's disease as it is located under the linkage region of AD on chromosome 4q, and functionally is involved in the microglia-mediated inflammatory response and amyloid-β clearance. The -196 to -174 del polymorphism affects the TLR2 gene and alters its promoter activity.Methods: We recruited 800 unrelated Northern Han Chinese individuals comprising 400 late-onset AD patients and 400 hea...更多
Background: Toll-like receptor 2 represents a reasonable functional and positional candidate gene for Alzheimer's disease as it is located under the linkage region of AD on chromosome 4q, and functionally is involved in the microglia-mediated inflammatory response and amyloid-β clearance. The -196 to -174 del polymorphism affects the TLR2 gene and alters its promoter activity.Methods: We recruited 800 unrelated Northern Han Chinese individuals comprising 400 late-onset AD patients and 400 healthy controls matched for gender and age. The -196 to -174 del polymorphism in the TLR2 gene was genotyped using the polymerase chain reaction method.Results: There were significant differences in genotype and allele frequencies of the -196 to -174 del polymorphism between LOAD patients and controls. The del allele was associated with an increased risk of LOAD . When these data were stratified by apolipoprotein E ε4 status, the observed association was confined to ApoE ε4 non-carriers. Logistic regression analysis suggested an association of LOAD with the polymorphism in a recessive model .Conclusions: Our data suggest that the -196 to -174 del/del genotype of TLR2 may increase risk of LOAD in a Northern Han Chinese population.收起
