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作者

Li Q.-W. Hou H.-F. Li X.-M. Li Y.-L. Han J.-J. Wang X.-N.

作者单位

Institute of Epidemiology, Taishan Medical College, Tai'an 271016, China

刊名

Chinese Journal of Endemiology

年份

2009

卷号

Vol.28 No.1

页码

41-43

ISSN

1000-4955

关键词

Articular Cartilage Deoxynivalenol Etiology

摘要

Objective: To observe toxic effect of deoxynivalenol on articular cartilage and synovium of New Zealand rabbit's knee joints. Methods: Fifteen male rabbits were divided randomly into 3 groups: control, high-dosage, and low-dosage group. In high-dosage and low-dosage group, saline solution of DON was injected with a dose of 0.10 and 0.05 mg/kg every 48 h into ear vein of rabbits. Specimen of articular cartilage and synovium were through pathology methods, and IL-1β, TNF-α, NO levels were assayed ...更多

Objective: To observe toxic effect of deoxynivalenol on articular cartilage and synovium of New Zealand rabbit's knee joints. Methods: Fifteen male rabbits were divided randomly into 3 groups: control, high-dosage, and low-dosage group. In high-dosage and low-dosage group, saline solution of DON was injected with a dose of 0.10 and 0.05 mg/kg every 48 h into ear vein of rabbits. Specimen of articular cartilage and synovium were through pathology methods, and IL-1β, TNF-α, NO levels were assayed in joint liquid, after 20 days. Results: Morphological changes were observed, such as synovium inflammative infiltration, chondrocytes deformation and necrosis under light microscope. The levels of IL-1β, TNF-α and NO had statistical significance in comparison between 3 groups. The levels of IL-1β, TNF-α and NO were significantly higher, high-dosage[,μg/ L; μmol/L] and low-dosage group[, μg/L; μmol/L] compared with control [, μmol/L; μmol/L], and high-dosage compared with low-dosage group. Conclusions: DON results in articular and synovial impairment, which has the symptom similar to osteoarthritis. DON probably causes osteoarthritis.收起

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