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作者

Song, Z. Ma, Z. Qu, K. Liu, S. Niu, W. Lin, T.

作者单位

Project and Data Management Office, Institute of Clinical Medicine, China-Japan Friendship Hospital, Beijing, 100029, China Department of Surgical Intensive Care Unit, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, China Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, China Department of Nephrology, Hemodialysis Center, Liaocheng People's Hospital, Taishan Medical College, Liaocheng, 252000, China a Department of Clinical Laboratory, Liaocheng People's Hospital, Taishan Medical College, Liaocheng, 252000, China

刊名

Oncotarget

年份

2017

卷号

Vol.8 No.59

页码

100631-100639

ISSN

1949-2553

关键词

Acute kidney injury Meta-analysis Prediction [TIMP-2] × [IGFBP7]

分类号

616.992

摘要

Acute kidney injury most commonly occurs in critically ill and postoperative patients. Tissue inhibitor of metalloproteinases-2 and insulin-like growth factor-binding protein 7 are two newly-identified urinary biomarkers that can help to detect early AKI, yet their predictive accuracies range widely. Here, we conduct a systematic meta-analysis to evaluate the diagnostic values of [TIMP- 2] × [IGFBP7] for AKI at different detection times and cutoff levels. Ten studies were meta-analyzed on 160...更多

Acute kidney injury most commonly occurs in critically ill and postoperative patients. Tissue inhibitor of metalloproteinases-2 and insulin-like growth factor-binding protein 7 are two newly-identified urinary biomarkers that can help to detect early AKI, yet their predictive accuracies range widely. Here, we conduct a systematic meta-analysis to evaluate the diagnostic values of [TIMP- 2] × [IGFBP7] for AKI at different detection times and cutoff levels. Ten studies were meta-analyzed on 1606 patients. Overall, urinary [TIMP-2] × [IGFBP7] had a pooled sensitivity of 58% and specificity of 79%. Subgroup analysis showed that the sensitivity and specificity were 0.72 and 0.58 with a cutoff value of 0.3 2 /1000, and 0.38 and 0.94 with a cutoff value of 2.0 2 /1000, respectively. Moreover, when 0.3 was chosen as the cutoff value, restricting analysis to patients who were tested within 4 hours showed a sensitivity of 0.71 and specificity of 0.73, with the AUROC of 0.75. When 2.0 was chosen as the cutoff value, the sensitivity and specificity were 0.43 and 0.93, respectively in patients who were tested within 24 hours, with the AUROC of 0.70. In summary, urinary [TIMP-2] × [IGFBP7] can predict the occurrence of AKI with moderate diagnostic accuracy. In the earlier administrative periods , 0.3 2/1000 is recommended to be used; whereas for patients who were administrated more than 24 hours, 2.0 2/1000 is more appropriate.收起

学科

【SCI学科】CELL BIOLOGY;ONCOLOGY 【ESI学科】MOLECULAR BIOLOGY & GENETICS

影响因子

2016年:5.168;2015年:5.008;2014年:6.359;2013年:6.627;2012年:6.636

文献类型

期刊

浏览量

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