获取途径

作者

Wang, Luqing Hu, Yanjun Xiang, Xiaohong Qu, Kai Teng, Yue

作者单位

Taishan Med Coll, Liaocheng Peoples Hosp, Dept Clin Lab, Liaocheng 252000, Peoples R China Taishan Med Coll, Liaocheng Peoples Hosp, Dept Nucl Med, Liaocheng 252000, Peoples R China Xi An Jiao Tong Univ, Affiliated Hosp 1, Dept Obstet & Gynecol, Xian 710061, Peoples R China Xi An Jiao Tong Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Xian 710061, Peoples R China

刊名

ONCOTARGET

年份

2017

卷号

Vol.8 No.38

页码

64191-64202

ISSN

1949-2553

关键词

long non-coding RNA epithelial ovarian cancer paclitaxel chemoresistance

分类号

616.992

摘要

Ovarian cancer is the most lethal gynecologic malignancy, characterized by late diagnosis, frequent relapse, and easy development of chemoresistance. Recent studies suggest that lncRNAs are involved in ovarian cancer onset and progression, as well as the resistance in paclitaxel-containing chemotherapy. However, the genome-wide expression pattern and associated functional implications of lncRNAs in paclitaxel-resistant ovarian cancer cells remain undetermined. In the present study, we identified...更多

Ovarian cancer is the most lethal gynecologic malignancy, characterized by late diagnosis, frequent relapse, and easy development of chemoresistance. Recent studies suggest that lncRNAs are involved in ovarian cancer onset and progression, as well as the resistance in paclitaxel-containing chemotherapy. However, the genome-wide expression pattern and associated functional implications of lncRNAs in paclitaxel-resistant ovarian cancer cells remain undetermined. In the present study, we identified a panel of lncRNAs aberrantly expressed in both paclitaxel resistant ovarian cancer tissues and cell lines, including XR_948297, XR_947831, XR_938728, XR_938392, NR_103801, NR_073113, and NR_036503. Moreover, the seven-lncRNA signature showed a relatively high predictive accuracy of chemoresistance with an area under the ROC curve of 0.93, and was associated with progression-free survival inovarian cancer patients . Our function prediction demonstrated that the seven-lncRNA signature was positively correlated with a cluster containing 129 genes enriched in insulin secretion-related pathway. Our findings suggest that the seven-lncRNA signature may be utilized as potent biomarkers for predicting chemoresistance for ovarian cancer patients with paclitaxel-containing chemotherapy.收起

学科

【SCI学科】CELL BIOLOGY;ONCOLOGY 【ESI学科】MOLECULAR BIOLOGY & GENETICS

影响因子

2016年:5.168;2015年:5.008;2014年:6.359;2013年:6.627;2012年:6.636

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期刊

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