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作者

Ru Wang, Youyuan Lv, Tao Dou, Qian Yang, Chunxiao Yu, Qingbo Guan

作者单位

com. ⁸ Shandong Institute of Endocrine and Metabolic Diseases, Jinan, 250021, Shandong, China. yuchx08@16 com. ¹⁰ Key Laboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging,Ministry of Education, Department of Endocrinology, Shandong Provincial Hospital of Affiliated to Shandong First Medical University, Jinan, 250021, Shandong, China. doctorguanqingbo@16 com. ⁹ Shandong Engineering Laboratory of Prevention and Control for Endocrine and Metabolic Diseases, Jinan, 250021, Shandong, China. yuchx08@16 com. ⁷ Shandong Key Laboratory of Endocrinology and Lipid Metabolism, Jinan, 250021, Shandong, China. yuchx08@16 com. ¹³ Shandong Engineering Laboratory of Prevention and Control for Endocrine and Metabolic Diseases, Jinan, 250021, Shandong, China. doctorguanqingbo@16 com. ¹² Shandong Institute of Endocrine and Metabolic Diseases, Jinan, 250021, Shandong, China. doctorguanqingbo@16 Affiliations ¹ Key Laboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging,Ministry of Education, Department of Endocrinology, Shandong Provincial Hospital of Affiliated to Shandong First Medical University, Jinan, 250021, Shandong, China. ² Shandong Key Laboratory of Endocrinology and Lipid Metabolism, Jinan, 250021, Shandong, China. ³ Shandong Institute of Endocrine and Metabolic Diseases, Jinan, 250021, Shandong, China. ⁴ Shandong Engineering Laboratory of Prevention and Control for Endocrine and Metabolic Diseases, Jinan, 250021, Shandong, China. ⁵ Internal Medicine Department of the Second Affiliated Hospital of Shandong University, Jinan, 250021, Shandong, China. ⁶ Key Laboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging,Ministry of Education, Department of Endocrinology, Shandong Provincial Hospital of Affiliated to Shandong First Medical University, Jinan, 250021, Shandong, China. yuchx08@16 com. ¹¹ Shandong Key Laboratory of Endocrinology and Lipid Metabolism, Jinan, 250021, Shandong, China. doctorguanqingbo@16 com.

刊名

Journal of ovarian research

年份

2024

卷号

Vol.17 No.1

页码

125

ISSN

1757-2215

关键词

Autoimmune thyroid disease Hyperthyroidism Hypothyroidism Ovarian Premature ovarian failure.

分类号

618

摘要

Thyroid hormones are essential for the proper functioning of the ovaries, and multiple studies have shown that thyroid abnormalities, especially during adolescence and reproductive age, can lead to lifelong ovarian dysfunction. Autoimmune thyroid disease , one of the most common organ specific autoimmune diseases, is mainly mediated by cellular autoimmune reactions, and has strong inflammatory infiltration and immune active cells, including chemokines and cytokines, which are important component...更多

Thyroid hormones are essential for the proper functioning of the ovaries, and multiple studies have shown that thyroid abnormalities, especially during adolescence and reproductive age, can lead to lifelong ovarian dysfunction. Autoimmune thyroid disease , one of the most common organ specific autoimmune diseases, is mainly mediated by cellular autoimmune reactions, and has strong inflammatory infiltration and immune active cells, including chemokines and cytokines, which are important components of ovarian aging. This suggests that autoimmune and inflammatory molecular processes may play a role in the emergence of ovarian dysfunction. The purpose of this review is to summarize recent in vivo and in vitro evidence of a complex relationship between AITD and ovarian dysfunction. AITD is closely related to the decline of ovarian function from the perspective of antibody, cytokine, oxidative stress, and genetic factors. Finally, some of the currently known treatments for AITD and hypo ovarian disease are summarized.收起

学科

【SCI学科】REPRODUCTIVE BIOLOGY 【ESI学科】BIOLOGY & BIOCHEMISTRY

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期刊

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