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作者

Zhou, Z.-H. Cui, X.-N. Xing, H.-G. Yan, R.-H. Yao, D.-K. Wang, L.-X.

作者单位

Department of Cardiology, Liaocheng People's Hospital, Taishan Medical University, Liaocheng, China a Department of Nuclear Medicine, Liaocheng People's Hospital, Taishan Medical University, Liaocheng, China School of Biomedical Sciences, Centre for Inland Health, Charles Sturt University, Wagga Wagga, NSW 2678, Australia Department of Cardiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China

刊名

Medical Principles and Practice

年份

2012

卷号

Vol.22 No.1

页码

24-28

ISSN

1011-7571

关键词

Cancer Metastasis Thyroglobulin Thyroid Vascular endothelial growth factor

摘要

Objective: To evaluate the changes and the prognostic value of serum vascular endothelial growth factor in patients with differentiated thyroid cancer . Subjects and Methods: A total of 79 patients with DTC and 30 healthy individuals were divided into four groups: a healthy control group ; DTC without recurrence ; DTC with local recurrence , and DTC with lung metastasis . Serum VEGF and thyroglobulin levels were measured in all patients. Results: Serum levels of VEGF were significantly high...更多

Objective: To evaluate the changes and the prognostic value of serum vascular endothelial growth factor in patients with differentiated thyroid cancer . Subjects and Methods: A total of 79 patients with DTC and 30 healthy individuals were divided into four groups: a healthy control group ; DTC without recurrence ; DTC with local recurrence , and DTC with lung metastasis . Serum VEGF and thyroglobulin levels were measured in all patients. Results: Serum levels of VEGF were significantly higher in the lung metastasis group than in the other three groups . Serum thyroglobulin concentration positively correlated with VEGF expression in patients with thyroid cancer recurrence. Multivariate Cox regression analysis showed that clinical staging , noncompliance with postoperative thyroxin replacement therapy and postoperative levels of thyroglobulin were independent predictors for thyroid cancer recurrence. Every additional 100 ng/l of serum VEGF levels increased the risk of thyroid cancer recurrence by 20.3%; but this did not reach statistical significance . Conclusions: Serum VEGF increased in patients with recurrent thyroid cancer following surgical therapies. The predictive value of serum VEGF requires further investigation.收起

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