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作者

Li, Yi Liu, Feng-Xia Yuan, Chao Meng, Lingguo

作者单位

Shandong Prov Shouguang Peoples Hosp, Shouguang, Peoples R China Taishan Med Univ, Affiliated Hosp, Tai An, Shandong, Peoples R China Juye Cty Hosp Tradit Chinese Med, Clin Lab, Juye, Peoples R China Shandong Univ, Shandong Prov Hosp, Dept Joint Surg, Jinan, Shandong, Peoples R China

刊名

MEDICINE

年份

2017

卷号

Vol.96 No.42

ISSN

0025-7974

关键词

haplotype osteonecrosis of the femoral head PAI-1 polymorphisms

摘要

This study aimed to analyze the correlation of the plasminogen activator inhibitor gene polymorphisms with susceptibility of osteonecrosis of the femoral head .This case-control study included 106 ONFH patients and 151 healthy controls. PAI-1 polymorphisms were genotyped by polymerase chain reaction with direct sequencing. The genotype distribution of polymorphism in the control group was checked with the status of Hardy-Weinberg equilibrium . The test was applied to compare the genotypes of...更多

This study aimed to analyze the correlation of the plasminogen activator inhibitor gene polymorphisms with susceptibility of osteonecrosis of the femoral head .This case-control study included 106 ONFH patients and 151 healthy controls. PAI-1 polymorphisms were genotyped by polymerase chain reaction with direct sequencing. The genotype distribution of polymorphism in the control group was checked with the status of Hardy-Weinberg equilibrium . The test was applied to compare the genotypes of polymorphisms between the case and control groups. The association intensity between PAI-1 polymorphisms and ONFH risk was estimated by odds ratios and 95% confidence intervals . The linkage disequilibrium of PAI-1 polymorphisms was analyzed by Haploview.We found that the genotypes and alleles of PAI-1 rs6092 and rs7242 polymorphisms had no obvious association with the risk of ONFH . But the strong linkage disequilibrium existed between rs6092 and rs7242 polymorphisms and haplotype G-T was significantly associated with the decreased risk of ONFH occurrence .PAI-1 rs6092 and rs7242 polymorphisms are not associated with ONFH development, but haplotype G-T may be a protective factor of ONFH.收起

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