获取途径

作者

Bao-Liang Sun Cheng-Bi Zheng Ming-Feng Yang Hui Yuan Su-Ming Zhang Le-Xin Wang

作者单位

Hui Yuan ( Affiliated Hospital, Taishan Medical College, Department of Neurology & Institute of Microcirculation, Taian, China) Ming-Feng Yang ( Taishan Medical College, Taian, China) Cheng-Bi Zheng ( Taishan Medical College, Taian, China) Bao-Liang Sun ( Affiliated Hospital, Taishan Medical College, Department of Neurology & Institute of Microcirculation, Taian, China)

刊名

Cellular and Molecular Neurobiology

年份

2009

卷号

Vol.29 No.2

页码

235-241

ISSN

0272-4340;1573-6830

关键词

Subarachnoid hemorrhage Secondary cerebral ischemia Microcirculation Rat

摘要

The study aimed to investigate the involvement of cerebral microcirculation turbulence after subarachnoid hemorrhage . Wistar rats were divided into non-SAH and SAH groups. Autologous arterial hemolysate was injected into rat’s cisterna magna to induce SAH. Changes of pial microcirculation within 2 h were observed. It was found that there were no obvious changes of the diameters, flow velocity, and fluid state of microvessels in non-SAH group. With the exception of rare linear-granular flow in A...更多

The study aimed to investigate the involvement of cerebral microcirculation turbulence after subarachnoid hemorrhage . Wistar rats were divided into non-SAH and SAH groups. Autologous arterial hemolysate was injected into rat’s cisterna magna to induce SAH. Changes of pial microcirculation within 2 h were observed. It was found that there were no obvious changes of the diameters, flow velocity, and fluid state of microvessels in non-SAH group. With the exception of rare linear-granular flow in A4 arteriole, linear flow was observed in most of the arterioles. There was no blood agglutination in any of the arterioles. After SAH, abnormal cerebral pial microcirculation was found. Spasm of microvessels, decreased blood flow, and agglutination of red blood cells occurred. Five minutes following the induction of SAH, the diameters of the arterioles and venules significantly decreased. The decreased diameters persisted for 2 h after cisternal injection. Decreased flow velocity of venules was found from 5 to 90 min after induction of SAH. Spasm of the basilar artery and increased brain malondialdehyde were also found after SAH. We concluded that cerebral microcirculation turbulence plays an important role in the development of secondary cerebral ischemia following SAH.收起

文献类型

期刊

浏览量

14