Synthesis, characterization and anticancer activity of a Cd complex with in situ formation of -1--pyrrolidin-2-one ligand

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作者单位: College of Pharmacy, Dalian Medical University, Dalian, 116044, China College of Chemistry and Chemical Engineering, Taishan University, Taian, 271021, China a Department of Chemical Engineering, Henan Polytechnic Institute, Nanyang, 473009, China

关键词: (E)-1-(5-chloro-2-hydroxybenzylideneamino)-pyrrolidin-2-one Anticancer activity Cadmium complex In situ synthesis

摘要: A new complex of Cd with -1--pyrrolidin-2-one [Cd 22DMF] was synthesized and characterized by elemental analysis, IR, TG and single-crystal X-ray diffraction. Where the HL ligand is formed in situ by the intramolecular nucleophilic substitution of -N′--4-butanehydrazide . The cadmium ion is hexacoordinated by two tridentate L - ligands and giving a distorted octahedral coordination geometry. A cytotoxicity of [Cd 22DMF] against liver and cervical cancer cells have been studied. The results re...更多; A new complex of Cd with -1--pyrrolidin-2-one [Cd 22DMF] was synthesized and characterized by elemental analysis, IR, TG and single-crystal X-ray diffraction. Where the HL ligand is formed in situ by the intramolecular nucleophilic substitution of -N′--4-butanehydrazide . The cadmium ion is hexacoordinated by two tridentate L - ligands and giving a distorted octahedral coordination geometry. A cytotoxicity of [Cd 22DMF] against liver and cervical cancer cells have been studied. The results revealed that this cadmium complex exhibited an effective and selective anticancer activity against HeLa over SMMC-7721 cell line with IC 50 of 1.54 ± 0.25 and 31.02 ± 3.76 μmol/dm -3 .收起

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