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作者

Weijie Cao Xingang Li Xiaoyu Zhang Jie Zhang Qi Sun Xizhu Xu Ming Sun Qiuyue Tian Qihuan Li Hao Wang Jiaonan Liu Xiaoni Meng Lijuan Wu Manshu Song Haifeng Hou Youxin Wang Wei Wang

作者单位

School of Medical and Health Sciences, Edith Cowan University, Perth 6027, Australia ua.ude.uce@il.gnagnix (X.L.) moc.361@uohfh (H.H.) Beijing Key Laboratory of Clinical Epidemiology, School of Public Health, Capital Medical University, Beijing 100069, China nc.ude.umcc@oacjw (W.C.) moc.621@yxzdyh (X.Z.) nc.ude.umcc@eijgnahz (J.Z.) moc.361@iqnusumc (Q.S.) moc.kooltuo@4021s.gnim (M.S.) moc.361@t__euyuiq (Q.T.) moc.361@kknauhiqil (Q.L.) ua.ude.uce@gnaw.oah (H.W.) moc.361@9999nanoaijuil (J.L.) moc.361@583inoaixgnem (X.M.) moc.361@710118naujuw (L.W.) nc.ude.umcc@smgnos (M.S.) School of Public Health, Taishan Medical University, Taian 271016, China nc.ude.cmst@uxzx

刊名

Cells

年份

2019

卷号

Vol.8 No.2

页码

159

ISSN

2073-4409

关键词

Mendelian randomization study single nucleotide polymorphisms instrumental variable ischemic stroke telomere length

摘要

Background: Epidemiological studies observing inconsistent associations of telomere length with ischemic stroke are susceptible to bias according to reverse causation and residual confounding. We aimed to assess the causal association between TL, IS, and the subtypes of IS, including large artery stroke , small vessel stroke , and cardioembolic stroke by performing a series of two-sample Mendelian randomization approaches. Methods: Seven single nucleotide polymorphisms were involved as cand...更多

Background: Epidemiological studies observing inconsistent associations of telomere length with ischemic stroke are susceptible to bias according to reverse causation and residual confounding. We aimed to assess the causal association between TL, IS, and the subtypes of IS, including large artery stroke , small vessel stroke , and cardioembolic stroke by performing a series of two-sample Mendelian randomization approaches. Methods: Seven single nucleotide polymorphisms were involved as candidate instrumental variables , summarized from a genome-wide meta-analysis including 37,684 participants of European descent. We analyzed the largest ever genome-wide association studies of stroke in Europe from the MEGASTROKE collaboration with 40,585 stroke cases and 406,111 controls. The weighted median , the penalized weighted median , the inverse variance weighted , the penalized inverse variance weighted , the robust inverse variance weighted , and the Mendelian randomization-Egger methods were conducted for the MR analysis to estimate a causal effect and detect the directional pleiotropy. Results: No significant association between genetically determined TL with overall IS, LAS, or CES were found . SVS was associated with TL by the RIVW method = 0.72, 95% confidence interval : 0.54–0.97, p = 0.028), after excluding rs9420907, rs10936599, and rs2736100. Conclusions: By a series of causal inference approaches using SNPs as IVs, no strong evidence to support the causal effect of shorter TL on IS and its subtypes were found.收起

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