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作者单位

首都医科大学宣武医院神经内科. 泰山医学院附属聊城市第二人民医院神经内科.

刊名

Progress in Modern Biomedicine

年份

2019

卷号

Vol.19 No.22

页码

4380-4383

ISSN

1673-6273

关键词

Cerebral hemorrhage Endothelin Ferritin High mobility group protein-1 Hypertension 脑出血 血管内皮素 铁蛋白 高血压 高迁移率族蛋白-1

摘要

Objective: To investigate the expression level of high mobility group protein-1, ferritin and vascular endothelin in patients with hypertensive intracerebral hemorrhage and its clinical significance. Methods: 96 patients with hypertensive cerebral hemorrhage who were treated in Liaocheng Second People’s Hospital Affiliated to Taishan Medical College from June 2014 to December 2017 were selected as the study group, and 80 healthy person in the hospital were used as the control group at the same t...更多

Objective: To investigate the expression level of high mobility group protein-1, ferritin and vascular endothelin in patients with hypertensive intracerebral hemorrhage and its clinical significance. Methods: 96 patients with hypertensive cerebral hemorrhage who were treated in Liaocheng Second People’s Hospital Affiliated to Taishan Medical College from June 2014 to December 2017 were selected as the study group, and 80 healthy person in the hospital were used as the control group at the same time. According to the degree of nerve defect, the study group was divided into mild group with 28 cases, moderate group with 43 cases and severe group with 25 cases, the study group was divided into good prognosis group with 62 cases and poor prognosis group with 34 cases according to the prognosis. The levels of serum HMGB-1, SF and ET-1 in the study group and the control group, patients with different degrees of nerve defect and different prognosis were compared. The correlation between serum levels of HMGB-1, SF, ET-1 and national institute of acute stroke scale in patients with hypertensive intracerebral hemorrhage were analyzed. Results:The serum levels of HMGB-1, SF and ET-1 in the study group were significantly higher than those in the control group. The level of serum HMGB-1, SF and ET-1 increased gradually with the increase of the degree of nerve defect, the differences were statistically significant. The serum HMGB-1, SF and ET-1 levels in the poor prognosis group were significantly higher than those in the good prognosis group. Pearson correlation analysis showed that serum HMGB-1, SF, ET-1 levels were positively correlated with NIHSS scores in patients with hypertensive intracerebral hemorrhage. Conclusion: The expression level of serum HMGB-1, SF and ET-1 in patients with hypertensive intracerebral hemorrhage is closely related to the degree of nerve defect and prognosis. The higher the levels of HMGB-1, SF and ET-1, the worse the prognosis of patients. Detection of these indicators has a certain reference value for the evaluation of patients’ condition and prognosis.收起

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