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作者

Weihong Li Daxin Wang Guohua Song Chunxia Zuo Xianfu Qiao Shucun Qin

作者单位

Taishan Med Univ, Dept Basic Med, Tai An 271000, Shandong, Peoples R China        Taishan Medical University Yangzhou Univ, Sch Med, Yangzhou 225001, Jiangsu, Peoples R China        Yangzhou University Taishan Med Univ, Inst Atherosclerosis, Tai An 271000, Shandong, Peoples R China        Taishan Medical University

刊名

Lipids in Health and Disease

年份

2010

卷号

Vol.9 No.1

页码

131

ISSN

1476-511x

关键词

LIPID-METABOLISM HYPERTRIGLYCERIDEMIA STATINS

摘要

It is designed to investigate the effects of combination therapy of allicin and fenofibrate on the endothelial and liver functions in rats with hyperlipidemia. The healthy male Wistar rats fed high fat diet were treated with fenofibrate alone, allicin alone and a lower dasage of combined therapy respectively for 8 weeks. The serum levels of cholesterol, triglyceride, nitrogen oxidative, alanine transferase and aspartate transferase were determined. Acetylcholine-induced endothelium-dependen...更多

It is designed to investigate the effects of combination therapy of allicin and fenofibrate on the endothelial and liver functions in rats with hyperlipidemia. The healthy male Wistar rats fed high fat diet were treated with fenofibrate alone, allicin alone and a lower dasage of combined therapy respectively for 8 weeks. The serum levels of cholesterol, triglyceride, nitrogen oxidative, alanine transferase and aspartate transferase were determined. Acetylcholine-induced endothelium-dependent vascular relaxation of aorta rings was tested, and the morphologic changes of liver tissue were observed. Compared with high fat diet control, fenofibrate alone or the combined therapy increased remarkably the levels of high density lipoprotein respectively . Both single and combined therapy of fenofibrate and allicin significantly enhanced the levels of NO , but the combined therapy had greatest high EDVR responses . Furthermore, the reduced levels of ALT and AST were significantly obvious in the combined therapy groups . In addition, the lower dosage of combined therapy significantly ameliorated severe fatty degeneration of liver cells occurred in the high fat diet fed rat although the single fenofibrate treatment showed spotty necrosis of liver cells and bile duct expansion. Combination therapy with allicin and fenofibrate can effectively enhance the protective effects on endothelial function and reduce the hepatic damage in rats with hyperlipidemia.收起

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